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MMP13 MMP13 MEP1B MEP1B G1T6B5_RABIT G1T6B5_RABIT ADAMTS18 ADAMTS18 AMZ2 AMZ2 MMP3 MMP3 ADAMTS17 ADAMTS17 MMP7 MMP7 ADAM22 ADAM22 PAPPA2 PAPPA2 ADAMTS1 ADAMTS1 ADAMTS14 ADAMTS14 G1TEH0_RABIT G1TEH0_RABIT MMP10 MMP10 LOC100338964 LOC100338964 ADAM21 ADAM21 LOC100344521 LOC100344521 ADAM1A ADAM1A ADAM33 ADAM33 ADAM6 ADAM6 ADAMTS10 ADAMTS10 G1TKW3_RABIT G1TKW3_RABIT G1TM10_RABIT G1TM10_RABIT LOC100339702 LOC100339702 ADAM6A ADAM6A G1TRE9_RABIT G1TRE9_RABIT ADAMTS2 ADAMTS2 G1TTF3_RABIT G1TTF3_RABIT MMP11 MMP11 ECE2 ECE2 MMP15 MMP15 ADAM30 ADAM30 LOC100339452 LOC100339452 LOC100358067 LOC100358067 AMZ1 AMZ1 ADAM29 ADAM29 G1U3U1_RABIT G1U3U1_RABIT MMP9 MMP9 ADAM18 ADAM18 ADAM23 ADAM23 LOC100339207 LOC100339207 ADAMTS16 ADAMTS16 ADAMTS20 ADAMTS20 ENSOCUP00000028629 ENSOCUP00000028629 BMP1 BMP1 ENSOCUP00000029581 ENSOCUP00000029581 ENSOCUP00000030103 ENSOCUP00000030103 MMP2 MMP2 MMP1 MMP1 ECE1 ECE1 ADAMTS8 ADAMTS8 ADAM10 ADAM10 ENSOCUP00000038178 ENSOCUP00000038178 ADAMTS7 ADAMTS7 MIPEP MIPEP MME MME ADAM19 ADAM19 KEL KEL ENSOCUP00000045483 ENSOCUP00000045483 ENSOCUP00000045488 ENSOCUP00000045488 ADAM8 ADAM8 ENSOCUP00000045838 ENSOCUP00000045838 ADAM2 ADAM2 ADAM9 ADAM9 ADAM28 ADAM28 MMP28 MMP28 MMP26 MMP26 ADAMTS3 ADAMTS3 MMP20 MMP20 ADAMTS5 ADAMTS5 MMP21 MMP21 ADAMDEC1 ADAMDEC1 ADAMTS6 ADAMTS6 MEP1A MEP1A PAPPA PAPPA MMP8 MMP8 MMP27 MMP27 ADAMTS15 ADAMTS15 ADAMTS9 ADAMTS9 G1SN82_RABIT G1SN82_RABIT G1SP03_RABIT G1SP03_RABIT PHEX PHEX ADAMTS12 ADAMTS12 ADAM15 ADAM15 MMP12 MMP12 ADAMTS19 ADAMTS19 G1SVE7_RABIT G1SVE7_RABIT ADAM12 ADAM12 NLN NLN ECEL1 ECEL1 ADAM17 ADAM17 MMP24 MMP24 ADAM11 ADAM11 MMP16 MMP16 ADAM7 ADAM7 ADAMTS4 ADAMTS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
MEP1BMeprin A subunit. (716 aa)
G1T6B5_RABITUncharacterized protein. (746 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1223 aa)
AMZ2Archaelysin family metallopeptidase 2. (360 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17. (1063 aa)
MMP7Matrix metallopeptidase 7. (273 aa)
ADAM22ADAM metallopeptidase domain 22. (866 aa)
PAPPA2Pappalysin 2. (1669 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (887 aa)
ADAMTS14ADAM metallopeptidase with thrombospondin type 1 motif 14. (1209 aa)
G1TEH0_RABITMetalloendopeptidase. (628 aa)
MMP10Matrix metallopeptidase 10. (477 aa)
LOC100338964Uncharacterized protein. (857 aa)
ADAM21ADAM metallopeptidase domain 21. (711 aa)
LOC100344521Uncharacterized protein. (748 aa)
ADAM1AUncharacterized protein. (919 aa)
ADAM33ADAM metallopeptidase domain 33. (795 aa)
ADAM6Uncharacterized protein. (731 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1103 aa)
G1TKW3_RABITUncharacterized protein. (672 aa)
G1TM10_RABITUncharacterized protein. (750 aa)
LOC100339702Uncharacterized protein. (845 aa)
ADAM6AUncharacterized protein. (729 aa)
G1TRE9_RABITUncharacterized protein. (828 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1174 aa)
G1TTF3_RABITUncharacterized protein. (613 aa)
MMP11Matrix metallopeptidase 11. (492 aa)
ECE2Endothelin converting enzyme 2. (770 aa)
MMP15U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the peptidase M10A family. (822 aa)
ADAM30ADAM metallopeptidase domain 30. (903 aa)
LOC100339452Uncharacterized protein. (809 aa)
LOC100358067Uncharacterized protein. (750 aa)
AMZ1Archaelysin family metallopeptidase 1. (462 aa)
ADAM29Uncharacterized protein. (703 aa)
G1U3U1_RABITUncharacterized protein. (1426 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
ADAM18ADAM metallopeptidase domain 18. (712 aa)
ADAM23ADAM metallopeptidase domain 23. (847 aa)
LOC100339207Uncharacterized protein. (743 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1192 aa)
ADAMTS20ADAM metallopeptidase with thrombospondin type 1 motif 20. (1845 aa)
ENSOCUP00000028629Metalloendopeptidase. (714 aa)
BMP1Metalloendopeptidase. (984 aa)
ENSOCUP00000029581Metalloendopeptidase. (828 aa)
ENSOCUP00000030103Uncharacterized protein. (520 aa)
MMP272 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (710 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
ECE1Endothelin converting enzyme 1. (783 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif 8. (804 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
ENSOCUP00000038178Uncharacterized protein. (678 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1654 aa)
MIPEPMitochondrial intermediate peptidase. (724 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
ADAM19ADAM metallopeptidase domain 19. (924 aa)
KELKell metallo-endopeptidase (Kell blood group). (732 aa)
ENSOCUP00000045483Uncharacterized protein. (762 aa)
ENSOCUP00000045488Uncharacterized protein. (829 aa)
ADAM8ADAM metallopeptidase domain 8. (978 aa)
ENSOCUP00000045838Uncharacterized protein. (646 aa)
ADAM2Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). (757 aa)
ADAM9ADAM metallopeptidase domain 9. (849 aa)
ADAM28ADAM metallopeptidase domain 28. (792 aa)
MMP28Matrix metallopeptidase 28. (521 aa)
MMP26Matrix metallopeptidase 26. (265 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3. (1198 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (931 aa)
MMP21Matrix metallopeptidase 21; Belongs to the peptidase M10A family. (567 aa)
ADAMDEC1ADAM like decysin 1. (495 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1116 aa)
MEP1AMeprin A subunit. (749 aa)
PAPPAPappalysin 1. (1498 aa)
MMP8Matrix metallopeptidase 8. (355 aa)
MMP27Matrix metallopeptidase 27. (527 aa)
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15. (950 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (2187 aa)
G1SN82_RABITZnMc domain-containing protein. (300 aa)
G1SP03_RABITUncharacterized protein. (557 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
ADAM15ADAM metallopeptidase domain 15. (881 aa)
MMP12Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family. (464 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19. (947 aa)
G1SVE7_RABITUncharacterized protein. (752 aa)
ADAM12ADAM metallopeptidase domain 12. (904 aa)
NLNNeurolysin, mitochondrial; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A; Belongs to the peptidase M3 family. (859 aa)
ECEL1Endothelin converting enzyme like 1. (779 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
MMP24Matrix metallopeptidase 24. (617 aa)
ADAM11ADAM metallopeptidase domain 11. (816 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
ADAM7ADAM metallopeptidase domain 7. (865 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (851 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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