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LOC100351873 LOC100351873 CAPZA1 CAPZA1 SPTB SPTB FLNA FLNA MYO19 MYO19 PFN1 PFN1 MYO1A MYO1A FSCN3 FSCN3 MYO1H MYO1H MYH7B MYH7B MYH4 MYH4 LOC100008687 LOC100008687 SPTBN4 SPTBN4 MYH9 MYH9 ARPC2 ARPC2 PFN2 PFN2 MYO18B MYO18B MYO5C MYO5C MYO5A MYO5A MYO1D MYO1D MARCKSL1 MARCKSL1 CFL2 CFL2 MYH8 MYH8 TNNI1 TNNI1 DNASE1 DNASE1 ARPC3 ARPC3 SPTBN5 SPTBN5 IMPACT IMPACT TPM1 TPM1 DST DST SPTBN2 SPTBN2 CAPZA3 CAPZA3 CAPZB CAPZB TMSB15B TMSB15B MYO9B MYO9B UTRN UTRN MYO1E MYO1E MYO3A MYO3A PLS1 PLS1 LCP1 LCP1 TMSB10 TMSB10 PHACTR2 PHACTR2 MYH1 MYH1 MYO3B MYO3B DSTN DSTN MYO7A MYO7A MYO7B MYO7B G1TQ93_RABIT G1TQ93_RABIT LOC100356070 LOC100356070 MYO9A MYO9A PLS3 PLS3 MYH7 MYH7 MYO5B MYO5B MYLK MYLK XIRP1 XIRP1 MYO6 MYO6 MYH13 MYH13 MYH11 MYH11 ACTN3 ACTN3 ARPC4 ARPC4 MYO10 MYO10 MYO1F MYO1F TMSB4 TMSB4 MYO1G MYO1G MYO1B MYO1B LASP1 LASP1 SYNE1 SYNE1 SPTBN1 SPTBN1 SNTA1 SNTA1 ENSOCUP00000029300 ENSOCUP00000029300 ENSOCUP00000029999 ENSOCUP00000029999 PHACTR3 PHACTR3 ENSOCUP00000031603 ENSOCUP00000031603 ALG14 ALG14 FLNB FLNB ENSOCUP00000034231 ENSOCUP00000034231 MYO16 MYO16 ACTR2 ACTR2 MYH10 MYH10 TPM2 TPM2 ACTN1 ACTN1 MYO18A MYO18A PHACTR1 PHACTR1 CLMN CLMN MACF1 MACF1 PHACTR4 PHACTR4 ENSOCUP00000048352 ENSOCUP00000048352 ACTN2 ACTN2 GC GC ENSOCUP00000047104 ENSOCUP00000047104 FLNC FLNC XIRP2 XIRP2 MYO1C MYO1C ENSOCUP00000045194 ENSOCUP00000045194 ENSOCUP00000044990 ENSOCUP00000044990 ENSOCUP00000044587 ENSOCUP00000044587 ENSOCUP00000043661 ENSOCUP00000043661
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LOC100351873F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2283 aa)
FLNAUncharacterized protein. (2617 aa)
MYO19Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (969 aa)
PFN1Profilin; Belongs to the profilin family. (104 aa)
MYO1AMyosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
FSCN3Fascin. (498 aa)
MYO1HMyosin IH; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1011 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1982 aa)
MYH4Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
LOC100008687Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (1822 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1920 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (322 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2502 aa)
MYO5CMyosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1742 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2013 aa)
MYO1DMyosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1021 aa)
MARCKSL1MARCKS-related protein; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (By similarity). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable). (189 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa)
MYH8Myosin heavy chain 8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
TNNI1Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (187 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Preferentially attacks double-stranded DNA and produces oligonucleotides with 5'-phospho and 3'-hydroxy termini. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly c [...] (281 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3514 aa)
IMPACTProtein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 ac [...] (449 aa)
TPM1Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
DSTDystonin. (5538 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2422 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1613 aa)
UTRNUtrophin. (3432 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1107 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1582 aa)
PLS1Plastin 1. (630 aa)
LCP1Lymphocyte cytosolic protein 1. (636 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
PHACTR2Phosphatase and actin regulator. (646 aa)
MYH1Myosin-4; Muscle contraction. (1938 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1320 aa)
DSTNADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (165 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2148 aa)
MYO7BMyosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2119 aa)
G1TQ93_RABITUncharacterized protein. (772 aa)
LOC100356070Profilin; Belongs to the profilin family. (153 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2504 aa)
PLS3Plastin 3. (630 aa)
MYH7Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
MYO5BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1848 aa)
MYLKMyosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] (1063 aa)
XIRP1Xin actin binding repeat containing 1. (1691 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
MYH13Skeletal muscle myosin heavy chain MyHC-EO/IIL; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
MYH11Myosin-11; Muscle contraction. (1944 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2067 aa)
MYO1FMyosin IF; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa)
TMSB4Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family. (44 aa)
MYO1GUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (509 aa)
MYO1BMyosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1128 aa)
LASP1LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). (373 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8708 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2156 aa)
SNTA1Alpha-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). (548 aa)
ENSOCUP00000029300ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (156 aa)
ENSOCUP00000029999F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (168 aa)
PHACTR3Phosphatase and actin regulator. (593 aa)
ENSOCUP00000031603Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1110 aa)
ALG14Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (526 aa)
FLNBFilamin-B; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). (2695 aa)
ENSOCUP00000034231Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (213 aa)
MYO16Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (937 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (425 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
TPM2Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. (352 aa)
ACTN1Actinin alpha 1. (1038 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2435 aa)
PHACTR1Phosphatase and actin regulator. (711 aa)
CLMNCalmin. (993 aa)
MACF1Microtubule actin crosslinking factor 1. (7577 aa)
PHACTR4Phosphatase and actin regulator. (781 aa)
ENSOCUP00000048352Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (146 aa)
ACTN2Actinin alpha 2. (893 aa)
GCVitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. (584 aa)
ENSOCUP00000047104Calponin-homology (CH) domain-containing protein. (267 aa)
FLNCFilamin C. (2628 aa)
XIRP2Xin actin binding repeat containing 2. (3529 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1000 aa)
ENSOCUP00000045194F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (229 aa)
ENSOCUP00000044990ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (176 aa)
ENSOCUP00000044587Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (295 aa)
ENSOCUP00000043661F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (275 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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