STRINGSTRING
LDLR LDLR OSBPL2 OSBPL2 APOB APOB ESYT1 ESYT1 STAR STAR VLDLR VLDLR OSBPL8 OSBPL8 APOA5 APOA5 OSBP2 OSBP2 LBP LBP APOC1 APOC1 SCP2 SCP2 ESYT3 ESYT3 OSBPL7 OSBPL7 ESYT2 ESYT2 OSBPL6 OSBPL6 ATP11B ATP11B TEX2 TEX2 GOT2 GOT2 OSBPL11 OSBPL11 OSBPL10 OSBPL10 OSBPL9 OSBPL9 OSBPL3 OSBPL3 OSBPL1A OSBPL1A APOA1 APOA1 APOA4 APOA4 PDZD8 PDZD8 CETP CETP OSBP OSBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (871 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (357 aa)
APOBApolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. (4573 aa)
ESYT1Extended synaptotagmin 1. (1091 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (351 aa)
VLDLRVery low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). (873 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (887 aa)
APOA5Uncharacterized protein. (463 aa)
OSBP2Oxysterol-binding protein; Belongs to the OSBP family. (918 aa)
LBPLipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa)
APOC1Apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification (By similarity). Modulates [...] (87 aa)
SCP2Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity); In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family. (546 aa)
ESYT3Extended synaptotagmin 3. (870 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (874 aa)
ESYT2Extended synaptotagmin 2. (863 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (967 aa)
ATP11BProbable phospholipid-transporting ATPase IF; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Isoform 2/RFBP appears to play a role in the subnuclear trafficking of transcription factors with RING motifs; Belongs to the cation transport [...] (1216 aa)
TEX2Testis expressed 2. (1134 aa)
GOT2Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (437 aa)
OSBPL11Oxysterol-binding protein; Belongs to the OSBP family. (765 aa)
OSBPL10Oxysterol-binding protein; Belongs to the OSBP family. (760 aa)
OSBPL9Oxysterol-binding protein; Belongs to the OSBP family. (746 aa)
OSBPL3Oxysterol-binding protein; Belongs to the OSBP family. (888 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (950 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (266 aa)
APOA4Apolipoprotein A-IV (Predicted). (390 aa)
PDZD8PDZ domain containing 8. (1150 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). (494 aa)
OSBPOxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] (809 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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