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LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (871 aa) | ||||
OSBPL2 | Oxysterol-binding protein; Belongs to the OSBP family. (357 aa) | ||||
APOB | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. (4573 aa) | ||||
ESYT1 | Extended synaptotagmin 1. (1091 aa) | ||||
STAR | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (351 aa) | ||||
VLDLR | Very low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). (873 aa) | ||||
OSBPL8 | Oxysterol-binding protein; Belongs to the OSBP family. (887 aa) | ||||
APOA5 | Uncharacterized protein. (463 aa) | ||||
OSBP2 | Oxysterol-binding protein; Belongs to the OSBP family. (918 aa) | ||||
LBP | Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa) | ||||
APOC1 | Apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification (By similarity). Modulates [...] (87 aa) | ||||
SCP2 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity); In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family. (546 aa) | ||||
ESYT3 | Extended synaptotagmin 3. (870 aa) | ||||
OSBPL7 | Oxysterol-binding protein; Belongs to the OSBP family. (874 aa) | ||||
ESYT2 | Extended synaptotagmin 2. (863 aa) | ||||
OSBPL6 | Oxysterol-binding protein; Belongs to the OSBP family. (967 aa) | ||||
ATP11B | Probable phospholipid-transporting ATPase IF; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Isoform 2/RFBP appears to play a role in the subnuclear trafficking of transcription factors with RING motifs; Belongs to the cation transport [...] (1216 aa) | ||||
TEX2 | Testis expressed 2. (1134 aa) | ||||
GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (437 aa) | ||||
OSBPL11 | Oxysterol-binding protein; Belongs to the OSBP family. (765 aa) | ||||
OSBPL10 | Oxysterol-binding protein; Belongs to the OSBP family. (760 aa) | ||||
OSBPL9 | Oxysterol-binding protein; Belongs to the OSBP family. (746 aa) | ||||
OSBPL3 | Oxysterol-binding protein; Belongs to the OSBP family. (888 aa) | ||||
OSBPL1A | Oxysterol-binding protein; Belongs to the OSBP family. (950 aa) | ||||
APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (266 aa) | ||||
APOA4 | Apolipoprotein A-IV (Predicted). (390 aa) | ||||
PDZD8 | PDZ domain containing 8. (1150 aa) | ||||
CETP | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). (494 aa) | ||||
OSBP | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] (809 aa) |