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| | G1U4M4_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (327 aa) |
| | RPS6KA2 | Non-specific serine/threonine protein kinase. (687 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CDKL2 | Cyclin-dependent kinase-like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (569 aa) |
| | STK32A | Serine/threonine kinase 32A; Belongs to the protein kinase superfamily. (396 aa) |
| | PSKH2 | Protein serine kinase H2; Belongs to the protein kinase superfamily. (385 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (490 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (537 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1009 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (297 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa) |
| | GRK4 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (572 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (474 aa) |
| | PSKH1 | Protein serine kinase H1; Belongs to the protein kinase superfamily. (424 aa) |
| | RPS6KA6 | Non-specific serine/threonine protein kinase. (690 aa) |
| | IFT52 | Intraflagellar transport 52. (752 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (666 aa) |
| | PRKD3 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | CDK15 | Cyclin dependent kinase 15; Belongs to the protein kinase superfamily. (430 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | CDK20 | Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (362 aa) |
| | EEF2K | Eukaryotic elongation factor 2 kinase. (725 aa) |
| | PAK2 | Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa) |
| | PRKG2 | cGMP-dependent protein kinase. (762 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (604 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (798 aa) |
| | ACVR1C | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa) |
| | CDK14 | Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuro [...] (469 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa) |
| | MAP3K21 | Mitogen-activated protein kinase kinase kinase. (1035 aa) |
| | CLK1 | CDC like kinase 1; Belongs to the protein kinase superfamily. (484 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (719 aa) |
| | PDIK1L | PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (341 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (292 aa) |
| | NEK7 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase. (508 aa) |
| | ENSOCUP00000047279 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
| | ENSOCUP00000047166 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa) |
| | LOC103347371 | Uncharacterized protein. (206 aa) |
| | LOC100358735 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (496 aa) |
| | CDC42BPB | CDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1584 aa) |
| | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa) |
| | RIOK1 | Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (568 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] (618 aa) |
| | STK32B | Serine/threonine kinase 32B; Belongs to the protein kinase superfamily. (401 aa) |
| | MAP4K5 | Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (814 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa) |
| | MARK1 | Non-specific serine/threonine protein kinase. (796 aa) |
| | PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (387 aa) |
| | MAP3K10 | Mitogen-activated protein kinase kinase kinase. (935 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa) |
| | MOK | MOK protein kinase; Belongs to the protein kinase superfamily. (420 aa) |
| | PHKG2 | Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa) |
| | MAPKAPK2 | MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa) |
| | MAST2 | Uncharacterized protein. (791 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CSNK1G3 | Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (456 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa) |
| | CDK8 | Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa) |
| | PIM2 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa) |
| | PRKCH | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa) |
| | CIT | Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2070 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | CDK13 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (418 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3635 aa) |
| | MARK3 | Non-specific serine/threonine protein kinase. (753 aa) |
| | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (875 aa) |
| | RIOK3 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (469 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (619 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (402 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa) |
| | CAMK1 | Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (371 aa) |
| | G1TKF2_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | G1TLG2_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (341 aa) |
| | G1TMA5_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | G1TPJ5_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa) |
| | CSNK2A1 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] (391 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa) |
| | G1TU91_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | G1TV38_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | TSSK6 | Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa) |
| | G1TVZ7_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa) |
| | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle; Implicated in the level of global muscle contraction and cardiac function (By similarity). Phosphorylates a specific serine in the N-terminus of a myosin light chain. (608 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa) |
| | LOC100358821 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (374 aa) |
| | SGK1 | Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peri [...] (526 aa) |
| | ENSOCUP00000038583 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (465 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (751 aa) |
| | CDC42BPA | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1833 aa) |
| | PAK3 | Non-specific serine/threonine protein kinase. (652 aa) |
| | STK17A | Serine/threonine-protein kinase 17A; Acts as a positive regulator of apoptosis. May also act as a regulator of cellular reactive oxygen species. (402 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1124 aa) |
| | PKN2 | Protein kinase N2. (996 aa) |
| | PRKCB | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa) |
| | LOC100352479 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa) |
| | ENSOCUP00000044665 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | MARK2 | Non-specific serine/threonine protein kinase. (788 aa) |
| | ENSOCUP00000043952 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (494 aa) |
| | MASTL | Microtubule associated serine/threonine kinase like. (906 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa) |
| | MKNK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa) |
| | DAPK2 | Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa) |
| | CLK4 | CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa) |
| | AMHR2 | Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (569 aa) |
| | GRK6 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (670 aa) |
| | ENSOCUP00000037731 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | LOC100341681 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (450 aa) |
| | CSNK1A1 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (378 aa) |
| | ENSOCUP00000037026 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa) |
| | ENSOCUP00000036823 | Mitogen-activated protein kinase. (254 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (585 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa) |
| | ENSOCUP00000035436 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (277 aa) |
| | LOC100356446 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (176 aa) |
| | STK17B | Serine/threonine kinase 17b; Belongs to the protein kinase superfamily. (399 aa) |
| | LOC100340551 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (409 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSOCUP00000034705 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa) |
| | ENSOCUP00000034337 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa) |
| | CSNK1G1 | Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (492 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | MAST4 | Microtubule associated serine/threonine kinase family member 4. (2482 aa) |
| | GRK5 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (278 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (416 aa) |
| | ENSOCUP00000033586 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (487 aa) |
| | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopath [...] (505 aa) |
| | PRKG1 | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] (686 aa) |
| | ENSOCUP00000040790 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (813 aa) |
| | TSSK1B | Testis specific serine kinase 1B; Belongs to the protein kinase superfamily. (345 aa) |
| | ENSOCUP00000040307 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (648 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa) |
| | ACVR1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (767 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | ENSOCUP00000030551 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (387 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (404 aa) |
| | STK38L | Non-specific serine/threonine protein kinase. (525 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (647 aa) |
| | PRKCA | Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (664 aa) |
| | G1U7P4_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa) |
| | NIM1K | NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa) |
| | U3KMH0_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | LOC100357951 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (496 aa) |
| | U3KNZ7_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (457 aa) |
| | G1U4A1_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | CDKL1 | Cyclin dependent kinase like 1; Belongs to the protein kinase superfamily. (333 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (681 aa) |
| | G1U2D1_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | TSSK2 | Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (354 aa) |
| | PRKCG | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (586 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (401 aa) |
| | MYLK | Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] (1063 aa) |
| | LOC100349328 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (500 aa) |
| | ENSOCUP00000028420 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | CLK2 | CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (442 aa) |
| | GRK7 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (656 aa) |
| | GRK3 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1131 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (870 aa) |
| | G1TWI6_RABIT | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
