45 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFB3	Transforming growth factor beta 3. (458 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (307 aa)
	ENSOCUP00000047714	Ubiquitin-like domain-containing protein. (71 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	ENSOCUP00000044498	Ribosomal_L40e domain-containing protein. (152 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ITGB8	Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). (772 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	ENSOCUP00000038446	Ubiquitin-like domain-containing protein. (87 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
	LOC100343047	Ubiquitin-like domain-containing protein. (77 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (291 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (873 aa)
	ENSOCUP00000032400	Uncharacterized protein. (531 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	ENSOCUP00000030467	Uncharacterized protein. (229 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (666 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (787 aa)
	SMAD3	SMAD family member 3. (230 aa)
	G1TZL0_RABIT	Ubiquitin-like domain-containing protein. (171 aa)
	SMAD7	Mothers against decapentaplegic homolog. (549 aa)
	G1TEF9_RABIT	PP1c_bdg domain-containing protein. (587 aa)
	UBE2M	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (799 aa)
	LTBP2	Latent transforming growth factor beta binding protein 2. (1809 aa)
	STRAP	Serine/threonine kinase receptor associated protein. (350 aa)
	SMURF2	E3 ubiquitin-protein ligase. (747 aa)
	ZFYVE9	Zinc finger FYVE domain-containing protein. (1425 aa)
	UBB	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	G1SK22_RABIT	Ubiquitin-like domain-containing protein. (188 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (830 aa)
	FBN1	Fibrillin 1. (2831 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	CBL	Cbl proto-oncogene. (837 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	G1SPR7_RABIT	Uncharacterized protein. (297 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1705 aa)
	MTMR4	Myotubularin related protein 4. (1195 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	ENSOCUP00000030467	ENSOCUP00000004160	ENSOCUP00000030467	Cbl proto-oncogene.	Uncharacterized protein.	0.826
CBL	ENSOCUP00000038446	ENSOCUP00000004160	ENSOCUP00000038446	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.652
CBL	ENSOCUP00000044498	ENSOCUP00000004160	ENSOCUP00000044498	Cbl proto-oncogene.	Ribosomal_L40e domain-containing protein.	0.729
CBL	ENSOCUP00000047714	ENSOCUP00000004160	ENSOCUP00000047714	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.650
CBL	G1SK22_RABIT	ENSOCUP00000004160	ENSOCUP00000003131	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.793
CBL	G1TZL0_RABIT	ENSOCUP00000004160	ENSOCUP00000022533	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.793
CBL	LOC100343047	ENSOCUP00000004160	ENSOCUP00000035405	Cbl proto-oncogene.	Ubiquitin-like domain-containing protein.	0.609
CBL	NEDD8	ENSOCUP00000004160	ENSOCUP00000002526	Cbl proto-oncogene.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.606
CBL	TGFBR2	ENSOCUP00000004160	ENSOCUP00000030537	Cbl proto-oncogene.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.767
CBL	UBB	ENSOCUP00000004160	ENSOCUP00000001111	Cbl proto-oncogene.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.826
CBL	UBE2M	ENSOCUP00000004160	ENSOCUP00000014290	Cbl proto-oncogene.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.585
ENSOCUP00000030467	CBL	ENSOCUP00000030467	ENSOCUP00000004160	Uncharacterized protein.	Cbl proto-oncogene.	0.826
ENSOCUP00000030467	ENSOCUP00000038446	ENSOCUP00000030467	ENSOCUP00000038446	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.882
ENSOCUP00000030467	ENSOCUP00000044498	ENSOCUP00000030467	ENSOCUP00000044498	Uncharacterized protein.	Ribosomal_L40e domain-containing protein.	0.934
ENSOCUP00000030467	ENSOCUP00000047714	ENSOCUP00000030467	ENSOCUP00000047714	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.795
ENSOCUP00000030467	G1SK22_RABIT	ENSOCUP00000030467	ENSOCUP00000003131	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.855
ENSOCUP00000030467	G1TZL0_RABIT	ENSOCUP00000030467	ENSOCUP00000022533	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.855
ENSOCUP00000030467	LOC100343047	ENSOCUP00000030467	ENSOCUP00000035405	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.848
ENSOCUP00000030467	NEDD8	ENSOCUP00000030467	ENSOCUP00000002526	Uncharacterized protein.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.795
ENSOCUP00000030467	SMAD2	ENSOCUP00000030467	ENSOCUP00000009717	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.400