STRINGSTRING
G1TZL0_RABIT G1TZL0_RABIT G1TZG8_RABIT G1TZG8_RABIT IL17RA IL17RA FOS FOS G1TUF4_RABIT G1TUF4_RABIT G1TSB1_RABIT G1TSB1_RABIT MAPK8 MAPK8 MAP2K7 MAP2K7 UBE2V1 UBE2V1 TAB1 TAB1 IL17F IL17F FNBP4 FNBP4 PPP2R1A PPP2R1A MAPK15 MAPK15 IL17A IL17A DUSP4 DUSP4 G1SK22_RABIT G1SK22_RABIT DUSP6 DUSP6 IRAK2 IRAK2 RPS6KA2 RPS6KA2 DUSP7 DUSP7 MAP3K7 MAP3K7 PPP2CA PPP2CA MAPK7 MAPK7 MAP3K20 MAP3K20 MAPKAPK2 MAPKAPK2 MAPK3 MAPK3 MAPK1 MAPK1 IL17RB IL17RB NOD2 NOD2 TAB2 TAB2 ATF2 ATF2 LOC100343655 LOC100343655 G1SFU8_RABIT G1SFU8_RABIT PPP2R5D PPP2R5D RIPK2 RIPK2 UBB UBB IL17RC IL17RC PPP2CB PPP2CB PPP4R4 PPP4R4 ATF1 ATF1 ENSOCUP00000046087 ENSOCUP00000046087 IKBKG IKBKG ENSOCUP00000044498 ENSOCUP00000044498 ENSOCUP00000044175 ENSOCUP00000044175 ELK1 ELK1 VRK3 VRK3 PPP2R1B PPP2R1B ENSOCUP00000047714 ENSOCUP00000047714 RPS6KA1 RPS6KA1 ENSOCUP00000040377 ENSOCUP00000040377 JUN JUN ENSOCUP00000038672 ENSOCUP00000038672 RPS6KA3 RPS6KA3 ENSOCUP00000038446 ENSOCUP00000038446 DUSP3 DUSP3 FOSL2 FOSL2 MAPK10 MAPK10 RPS6KA5 RPS6KA5 TAB3 TAB3 MAP2K6 MAP2K6 ATF7 ATF7 CREB1 CREB1 MAPKAPK3 MAPKAPK3 NOD1 NOD1 MAP2K4 MAP2K4 LOC100343047 LOC100343047 ENSOCUP00000035366 ENSOCUP00000035366 CREB5 CREB5 ENSOCUP00000035121 ENSOCUP00000035121 IL17RE IL17RE RELCH RELCH MAPK9 MAPK9 MAP2K3 MAP2K3 ENSOCUP00000030467 ENSOCUP00000030467 IL25 IL25 IRAK1 IRAK1 PPP4R1 PPP4R1 TRAF6 TRAF6 G1U317_RABIT G1U317_RABIT NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G1TZL0_RABITUbiquitin-like domain-containing protein. (171 aa)
G1TZG8_RABITUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (115 aa)
IL17RAInterleukin 17 receptor A. (860 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
G1TUF4_RABITSER_THR_PHOSPHATASE domain-containing protein. (215 aa)
G1TSB1_RABITSerine/threonine-protein phosphatase. (282 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (139 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IL17FInterleukin 17F. (163 aa)
FNBP4Formin binding protein 4. (1016 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (542 aa)
MAPK15Mitogen-activated protein kinase. (619 aa)
IL17AInterleukin 17A. (153 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (386 aa)
G1SK22_RABITUbiquitin-like domain-containing protein. (188 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (592 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (687 aa)
DUSP7Uncharacterized protein. (358 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (875 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
IL17RBInterleukin 17 receptor B. (493 aa)
NOD2Nucleotide oligomerization domain 2 protein. (1013 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
LOC100343655UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
G1SFU8_RABITKID domain-containing protein. (127 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family. (553 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
UBBUbiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
IL17RCInterleukin 17 receptor C. (770 aa)
PPP2CBSerine/threonine-protein phosphatase. (350 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (834 aa)
ATF1Activating transcription factor 1. (266 aa)
ENSOCUP00000046087UBIQUITIN_CONJUGAT_2 domain-containing protein. (97 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
ENSOCUP00000044498Ribosomal_L40e domain-containing protein. (152 aa)
ENSOCUP00000044175UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
ELK1ETS transcription factor ELK1. (512 aa)
VRK3VRK serine/threonine kinase 3. (479 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (714 aa)
ENSOCUP00000047714Ubiquitin-like domain-containing protein. (71 aa)
RPS6KA1Ribosomal protein S6 kinase. (813 aa)
ENSOCUP00000040377Uncharacterized protein. (356 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
ENSOCUP00000038672BZIP domain-containing protein. (116 aa)
RPS6KA3Ribosomal protein S6 kinase. (751 aa)
ENSOCUP00000038446Ubiquitin-like domain-containing protein. (87 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (170 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (730 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
LOC100343047Ubiquitin-like domain-containing protein. (77 aa)
ENSOCUP00000035366IL17R_fnIII_D1 domain-containing protein. (331 aa)
CREB5cAMP responsive element binding protein 5. (526 aa)
ENSOCUP00000035121Serine/threonine-protein phosphatase. (279 aa)
IL17REInterleukin 17 receptor E. (762 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1223 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (374 aa)
ENSOCUP00000030467Uncharacterized protein. (229 aa)
IL25Interleukin 25. (177 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (947 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
G1U317_RABITUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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