STRINGSTRING
G1TSB1_RABIT G1TSB1_RABIT ANOS1 ANOS1 FGF2 FGF2 UBB UBB FLRT3 FLRT3 FGF6 FGF6 GAB1 GAB1 G1SK22_RABIT G1SK22_RABIT PTPN11 PTPN11 CBL CBL SPRED2 SPRED2 PIK3R1 PIK3R1 FGF10 FGF10 SPRY2 SPRY2 KRAS KRAS FGF5 FGF5 MAPK1 MAPK1 MAPK3 MAPK3 FGF1 FGF1 PPP2CA PPP2CA SHC1 SHC1 FRS2 FRS2 FGF4 FGF4 FLRT2 FLRT2 G1TL27_RABIT G1TL27_RABIT G1TM34_RABIT G1TM34_RABIT FLRT1 FLRT1 KL KL NRAS NRAS SOS1 SOS1 G1TUF4_RABIT G1TUF4_RABIT PLCG1 PLCG1 G1TZL0_RABIT G1TZL0_RABIT G1U373_RABIT G1U373_RABIT FGF23 FGF23 PIK3CA PIK3CA FNDC3A FNDC3A ENSOCUP00000030467 ENSOCUP00000030467 CSDE1 CSDE1 BRAF BRAF FGF18 FGF18 FNDC3B FNDC3B ENSOCUP00000035121 ENSOCUP00000035121 LOC100343047 LOC100343047 ENSOCUP00000035577 ENSOCUP00000035577 FRS3 FRS3 ENSOCUP00000038446 ENSOCUP00000038446 SPRED1 SPRED1 FGF17 FGF17 FGFR1 FGFR1 GRB2 GRB2 MKNK1 MKNK1 ENSOCUP00000044498 ENSOCUP00000044498
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G1TSB1_RABITSerine/threonine-protein phosphatase. (282 aa)
ANOS1Uncharacterized protein. (342 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
UBBUbiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GAB1GRB2 associated binding protein 1. (750 aa)
G1SK22_RABITUbiquitin-like domain-containing protein. (188 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CBLCbl proto-oncogene. (837 aa)
SPRED2Sprouty related EVH1 domain containing 2. (417 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
SHC1SHC adaptor protein 1. (474 aa)
FRS2Fibroblast growth factor receptor substrate 2. (491 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
G1TL27_RABITUncharacterized protein. (99 aa)
G1TM34_RABITUncharacterized protein. (1343 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (675 aa)
KLKlotho. (1005 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
G1TUF4_RABITSER_THR_PHOSPHATASE domain-containing protein. (215 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
G1TZL0_RABITUbiquitin-like domain-containing protein. (171 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSOCUP00000030467Uncharacterized protein. (229 aa)
CSDE1Cold shock domain containing E1. (851 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
FNDC3BFibronectin type III domain containing 3B. (1207 aa)
ENSOCUP00000035121Serine/threonine-protein phosphatase. (279 aa)
LOC100343047Ubiquitin-like domain-containing protein. (77 aa)
ENSOCUP00000035577Uncharacterized protein. (517 aa)
FRS3IRS-type PTB domain-containing protein. (543 aa)
ENSOCUP00000038446Ubiquitin-like domain-containing protein. (87 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
FGF17Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
ENSOCUP00000044498Ribosomal_L40e domain-containing protein. (152 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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