STRINGSTRING
PSMA1 PSMA1 UBB UBB LTBR LTBR TNFRSF17 TNFRSF17 PSMB8 PSMB8 TNFRSF9 TNFRSF9 CUL1 CUL1 PSMB3 PSMB3 PSME2 PSME2 BIRC7 BIRC7 G1SK22_RABIT G1SK22_RABIT CD70 CD70 TRAF3 TRAF3 CD40LG CD40LG PSMD9 PSMD9 PSMC5 PSMC5 PSMD4 PSMD4 TNFRSF11A TNFRSF11A PSMD5 PSMD5 NFKB2 NFKB2 PSMC1 PSMC1 PSMB10 PSMB10 LTA LTA TNF TNF LTB LTB PSMD2 PSMD2 CD27 CD27 UBA3 UBA3 PSMD11 PSMD11 TNFSF4 TNFSF4 PSMD7 PSMD7 PSMA8 PSMA8 PSMB7 PSMB7 TRAF5 TRAF5 TNFSF8 TNFSF8 BIRC3 BIRC3 PSMC2 PSMC2 PSMA3 PSMA3 PSMD10 PSMD10 TNFRSF11B TNFRSF11B TNFSF15 TNFSF15 PSMB6 PSMB6 PSMA2 PSMA2 TNLG7A TNLG7A PSMC6 PSMC6 PSMB5 PSMB5 PSMB11 PSMB11 G1T4W9_RABIT G1T4W9_RABIT PSMB2 PSMB2 PSMA4 PSMA4 PSMA5 PSMA5 BIRC2 BIRC2 PSMD12 PSMD12 TNFRSF1B TNFRSF1B TNFSF10 TNFSF10 PSMB4 PSMB4 EDA EDA TNFRSF8 TNFRSF8 UBE2M UBE2M TNFSF11 TNFSF11 EDAR EDAR PSME3 PSME3 FBXW11 FBXW11 TNFSF18 TNFSF18 TNFRSF25 TNFRSF25 PSMC3 PSMC3 TNFRSF12A TNFRSF12A LOC103349620 LOC103349620 TNFSF13 TNFSF13 SKP1 SKP1 TNFRSF13B TNFRSF13B G1TZL0_RABIT G1TZL0_RABIT PSMD6 PSMD6 PSMD8 PSMD8 PSME1 PSME1 U3KN18_RABIT U3KN18_RABIT PSME4 PSME4 ENSOCUP00000028034 ENSOCUP00000028034 PSMD3 PSMD3 ENSOCUP00000029087 ENSOCUP00000029087 ENSOCUP00000030327 ENSOCUP00000030327 ENSOCUP00000030467 ENSOCUP00000030467 ENSOCUP00000031260 ENSOCUP00000031260 CHUK CHUK PSMD13 PSMD13 ENSOCUP00000032553 ENSOCUP00000032553 ENSOCUP00000032799 ENSOCUP00000032799 CD40 CD40 ENSOCUP00000034957 ENSOCUP00000034957 LOC100343047 LOC100343047 PSMB1 PSMB1 PSMB9 PSMB9 TNFSF12 TNFSF12 ENSOCUP00000038446 ENSOCUP00000038446 EDA2R EDA2R ENSOCUP00000038972 ENSOCUP00000038972 ENSOCUP00000039348 ENSOCUP00000039348 PSMD1 PSMD1 ENSOCUP00000044133 ENSOCUP00000044133 ENSOCUP00000044498 ENSOCUP00000044498 EDARADD EDARADD TNFRSF1A TNFRSF1A TNFSF14 TNFSF14 ENSOCUP00000046340 ENSOCUP00000046340 ENSOCUP00000046782 ENSOCUP00000046782 PSMD14 PSMD14 ENSOCUP00000047247 ENSOCUP00000047247 PSMA6 PSMA6 ENSOCUP00000047714 ENSOCUP00000047714 PSMF1 PSMF1 ENSOCUP00000048996 ENSOCUP00000048996 BTRC BTRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA1Proteasome subunit alpha type. (263 aa)
UBBUbiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
LTBRLymphotoxin beta receptor. (414 aa)
TNFRSF17TNF receptor superfamily member 17. (183 aa)
PSMB8Proteasome subunit beta. (276 aa)
TNFRSF9TNF receptor superfamily member 9. (258 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSME2Proteasome activator subunit 2. (239 aa)
BIRC7Baculoviral IAP repeat containing 7. (278 aa)
G1SK22_RABITUbiquitin-like domain-containing protein. (188 aa)
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (297 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
PSMD9PDZ domain-containing protein. (283 aa)
PSMC5AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
PSMD4Proteasome 26S subunit, non-ATPase, 4 (Predicted). (380 aa)
TNFRSF11ATNFR-Cys domain-containing protein. (349 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
NFKB2Nuclear factor kappa B subunit 2. (810 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
PSMB10Proteasome subunit beta. (273 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (197 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (1051 aa)
CD27CD27 molecule. (260 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (463 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. (216 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (379 aa)
PSMA8Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (349 aa)
PSMB7Proteasome subunit beta. (271 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNFSF8TNF superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
BIRC3Baculoviral IAP repeat containing 3. (591 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMA3Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (326 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
TNFSF15TNF superfamily member 15. (340 aa)
PSMB6Proteasome subunit beta 6. (338 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
TNLG7ATumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (362 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMB11Proteasome subunit beta. (303 aa)
G1T4W9_RABITBaffR-Tall_bind domain-containing protein. (271 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA4Proteasome subunit alpha type. (270 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
BIRC2Baculoviral IAP repeat containing 2. (601 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (447 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (304 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (386 aa)
TNFRSF8TNF receptor superfamily member 8. (581 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
EDAREctodysplasin A receptor. (449 aa)
PSME3Proteasome activator subunit 3. (265 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
TNFSF18TNF superfamily member 18. (217 aa)
TNFRSF25TNF receptor superfamily member 25. (416 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
TNFRSF12ATNF receptor superfamily member 12A. (80 aa)
LOC103349620DUF3437 domain-containing protein. (299 aa)
TNFSF13TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (250 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
TNFRSF13BTNF receptor superfamily member 13B. (276 aa)
G1TZL0_RABITUbiquitin-like domain-containing protein. (171 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (391 aa)
PSME1Proteasome activator subunit 1. (249 aa)
U3KN18_RABITAAA domain-containing protein. (368 aa)
PSME4Uncharacterized protein. (1805 aa)
ENSOCUP00000028034ANK_REP_REGION domain-containing protein. (131 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
ENSOCUP00000029087AAA domain-containing protein; Belongs to the AAA ATPase family. (425 aa)
ENSOCUP00000030327AAA domain-containing protein; Belongs to the AAA ATPase family. (351 aa)
ENSOCUP00000030467Uncharacterized protein. (229 aa)
ENSOCUP00000031260Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
PSMD13Uncharacterized protein. (356 aa)
ENSOCUP00000032553PROTEASOME_ALPHA_1 domain-containing protein. (168 aa)
ENSOCUP00000032799AAA domain-containing protein; Belongs to the AAA ATPase family. (528 aa)
CD40Uncharacterized protein. (494 aa)
ENSOCUP00000034957Uncharacterized protein. (157 aa)
LOC100343047Ubiquitin-like domain-containing protein. (77 aa)
PSMB1Proteasome subunit beta 1. (367 aa)
PSMB9Uncharacterized protein. (354 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (248 aa)
ENSOCUP00000038446Ubiquitin-like domain-containing protein. (87 aa)
EDA2REctodysplasin A2 receptor. (332 aa)
ENSOCUP00000038972Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (67 aa)
ENSOCUP00000039348Uncharacterized protein. (85 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
ENSOCUP00000044133Proteasome endopeptidase complex. (158 aa)
ENSOCUP00000044498Ribosomal_L40e domain-containing protein. (152 aa)
EDARADDEDAR associated death domain. (243 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
TNFSF14TNF superfamily member 14. (241 aa)
ENSOCUP00000046340RHD domain-containing protein. (343 aa)
ENSOCUP00000046782Skp1_POZ domain-containing protein. (57 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (317 aa)
ENSOCUP00000047247ANK_REP_REGION domain-containing protein. (106 aa)
PSMA6Proteasome endopeptidase complex. (264 aa)
ENSOCUP00000047714Ubiquitin-like domain-containing protein. (71 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ENSOCUP00000048996Uncharacterized protein; Belongs to the SKP1 family. (175 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (34%) [HD]