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AKT2 AKT2 TLR9 TLR9 GRB2 GRB2 FGF9 FGF9 FGF6 FGF6 PDPK1 PDPK1 PIK3R4 PIK3R4 GAB1 GAB1 FGF19 FGF19 PTPN11 PTPN11 FLT3 FLT3 PIK3CB PIK3CB PIK3R1 PIK3R1 SPEM1 SPEM1 SPEM2 SPEM2 IRS1 IRS1 FGF16 FGF16 PDE3B PDE3B FGF10 FGF10 KLB KLB IRS4 IRS4 FGF5 FGF5 MAPK1 MAPK1 MAPK3 MAPK3 FGF1 FGF1 GRB10 GRB10 SHC1 SHC1 FRS2 FRS2 INSR INSR FGFR1 FGFR1 FGF17 FGF17 FGFR4 FGFR4 FGF7 FGF7 GAB2 GAB2 FGF4 FGF4 KL KL SOS1 SOS1 INS INS G1U373_RABIT G1U373_RABIT FGF23 FGF23 PIK3CA PIK3CA PIK3C3 PIK3C3 FGFR2 FGFR2 FGF18 FGF18 LOC100339305 LOC100339305 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2AKT serine/threonine kinase 2. (442 aa)
TLR9TIR domain-containing protein. (1027 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1373 aa)
GAB1GRB2 associated binding protein 1. (750 aa)
FGF19Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (218 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SPEM1Spermatid maturation 1. (312 aa)
SPEM2SPEM family member 2. (501 aa)
IRS1Insulin receptor substrate 1. (1220 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDE3BPhosphodiesterase. (1117 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
KLBKlotho beta. (1112 aa)
IRS4Insulin receptor substrate 4. (1176 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GRB10Growth factor receptor bound protein 10. (550 aa)
SHC1SHC adaptor protein 1. (474 aa)
FRS2Fibroblast growth factor receptor substrate 2. (491 aa)
INSRTyrosine-protein kinase receptor. (1377 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
FGF17Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa)
FGFR4Fibroblast growth factor receptor. (862 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
KLKlotho. (1005 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
LOC100339305Uncharacterized protein. (506 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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