STRINGSTRING
TP53 TP53 ZFHX4 ZFHX4 SMAD4 SMAD4 G1SV95_RABIT G1SV95_RABIT ZFHX3 ZFHX3 ZFHX2 ZFHX2 NINJ2 NINJ2 G1U940_RABIT G1U940_RABIT SMAD3 SMAD3 LOC103345451 LOC103345451 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
ZFHX4Zinc finger homeobox 4. (3619 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
ZFHX3Zinc finger homeobox 3. (2758 aa)
ZFHX2Zinc finger homeobox 2. (2541 aa)
NINJ2Uncharacterized protein. (246 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
SMAD3SMAD family member 3. (230 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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