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ARHGEF28 ARHGEF28 TGIF2 TGIF2 ZFYVE9 ZFYVE9 UBB UBB ACVR1 ACVR1 NEDD8 NEDD8 G1SIQ0_RABIT G1SIQ0_RABIT IRX5 IRX5 CCNC CCNC G1SK22_RABIT G1SK22_RABIT ITGB1 ITGB1 FBN1 FBN1 SMAD4 SMAD4 ATP1B4 ATP1B4 IRX6 IRX6 FST FST CBL CBL INHBB INHBB TGFB2 TGFB2 RBL1 RBL1 G1SPR7_RABIT G1SPR7_RABIT SMAD6 SMAD6 TFDP1 TFDP1 CCNT1 CCNT1 CCNK CCNK PARD3B PARD3B G1SV95_RABIT G1SV95_RABIT PARD6A PARD6A IRX2 IRX2 ACVR1C ACVR1C LTBP1 LTBP1 SNW1 SNW1 MTMR4 MTMR4 E2F4 E2F4 BMP10 BMP10 LDLRAD4 LDLRAD4 PARD3 PARD3 ENSOCUP00000047714 ENSOCUP00000047714 SMAD5 SMAD5 ITGA8 ITGA8 ENSOCUP00000045925 ENSOCUP00000045925 PPM1A PPM1A ENSOCUP00000044498 ENSOCUP00000044498 ENSOCUP00000044284 ENSOCUP00000044284 BMPR1B BMPR1B LOC100343047 LOC100343047 CHRDL1 CHRDL1 TGFBR1 TGFBR1 SMAD9 SMAD9 BMPR2 BMPR2 SP1 SP1 CCNQ CCNQ ENSOCUP00000037329 ENSOCUP00000037329 HDAC1 HDAC1 ENSOCUP00000038446 ENSOCUP00000038446 F11R F11R NEDD4L NEDD4L ITGAV ITGAV RNF111 RNF111 MEIS3 MEIS3 NOG NOG AMHR2 AMHR2 ENSOCUP00000041840 ENSOCUP00000041840 DRAP1 DRAP1 ITGB8 ITGB8 TGFBR2 TGFBR2 LOC103345451 LOC103345451 UBE2D1 UBE2D1 CER1 CER1 NCOR1 NCOR1 MKX MKX SMAD2 SMAD2 TGFB3 TGFB3 BMP2 BMP2 SMURF2 SMURF2 E2F5 E2F5 SKIL SKIL GDF2 GDF2 MAPK1 MAPK1 MAPK3 MAPK3 TGIF1 TGIF1 STRAP STRAP LTBP2 LTBP2 G1T7Q0_RABIT G1T7Q0_RABIT ITGB5 ITGB5 CDK8 CDK8 ZCCHC4 ZCCHC4 SMURF1 SMURF1 ACVR2A ACVR2A TRIM33 TRIM33 TFDP2 TFDP2 UBE2M UBE2M BMPR1A BMPR1A G1TEF9_RABIT G1TEF9_RABIT PARP1 PARP1 ACVR1B ACVR1B USP9X USP9X ACVRL1 ACVRL1 G1TJP7_RABIT G1TJP7_RABIT SMAD7 SMAD7 G1TQE3_RABIT G1TQE3_RABIT TGIF2LX TGIF2LX G1TZL0_RABIT G1TZL0_RABIT IRX1 IRX1 G1U6D1_RABIT G1U6D1_RABIT CGN CGN SMAD3 SMAD3 FSTL1 FSTL1 ENSOCUP00000028580 ENSOCUP00000028580 ARHGEF18 ARHGEF18 ITGB6 ITGB6 ZFYVE16 ZFYVE16 FURIN FURIN ENSOCUP00000030467 ENSOCUP00000030467 ENSOCUP00000032400 ENSOCUP00000032400 ITGB3 ITGB3 CHRDL2 CHRDL2 CCNT2 CCNT2 PMEPA1 PMEPA1 SMAD1 SMAD1 ENSOCUP00000034777 ENSOCUP00000034777 GREM2 GREM2 INHBA INHBA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGEF28Rho guanine nucleotide exchange factor 28. (1624 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
UBBUbiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
G1SIQ0_RABITUBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa)
IRX5Iroquois homeobox 5. (439 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
G1SK22_RABITUbiquitin-like domain-containing protein. (188 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
FBN1Fibrillin 1. (2831 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (352 aa)
IRX6Iroquois homeobox 6. (375 aa)
FSTFollistatin. (310 aa)
CBLCbl proto-oncogene. (837 aa)
INHBBInhibin subunit beta B. (302 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
G1SPR7_RABITUncharacterized protein. (297 aa)
SMAD6MH2 domain-containing protein. (220 aa)
TFDP1Transcription factor. (410 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (1010 aa)
CCNKCyclin K; Belongs to the cyclin family. (559 aa)
PARD3BPar-3 family cell polarity regulator beta. (1205 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
IRX2Iroquois homeobox 2. (335 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1705 aa)
SNW1SNW domain containing 1. (536 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
E2F4E2F_TDP domain-containing protein. (395 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (307 aa)
PARD3Par-3 family cell polarity regulator. (1340 aa)
ENSOCUP00000047714Ubiquitin-like domain-containing protein. (71 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
PPM1AProtein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). (385 aa)
ENSOCUP00000044498Ribosomal_L40e domain-containing protein. (152 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
LOC100343047Ubiquitin-like domain-containing protein. (77 aa)
CHRDL1Chordin like 1. (578 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
SMAD9Mothers against decapentaplegic homolog. (441 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
SP1Sp1 transcription factor. (792 aa)
CCNQCyclin Q; Belongs to the cyclin family. (252 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (550 aa)
ENSOCUP00000038446Ubiquitin-like domain-containing protein. (87 aa)
F11RF11 receptor. (314 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1239 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
RNF111Ring finger protein 111. (993 aa)
MEIS3Meis homeobox 3. (523 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (569 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
DRAP1CBFD_NFYB_HMF domain-containing protein. (362 aa)
ITGB8Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). (772 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
UBE2D1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
NCOR1Nuclear receptor corepressor 1. (2374 aa)
MKXMohawk homeobox. (357 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
E2F5E2F_CC-MB domain-containing protein. (184 aa)
SKILSKI like proto-oncogene. (683 aa)
GDF2Growth differentiation factor 2. (434 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
TGIF1TGFB induced factor homeobox 1. (452 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1809 aa)
G1T7Q0_RABITUncharacterized protein. (269 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (511 aa)
SMURF1E3 ubiquitin-protein ligase. (737 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
TRIM33Tripartite motif containing 33. (1059 aa)
TFDP2Transcription factor. (446 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
G1TEF9_RABITPP1c_bdg domain-containing protein. (587 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2575 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
G1TJP7_RABITSANT domain-containing protein. (1611 aa)
SMAD7Mothers against decapentaplegic homolog. (549 aa)
G1TQE3_RABITFork-head domain-containing protein. (520 aa)
TGIF2LXHomeobox domain-containing protein. (214 aa)
G1TZL0_RABITUbiquitin-like domain-containing protein. (171 aa)
IRX1Iroquois homeobox 1. (439 aa)
G1U6D1_RABITE2F_TDP domain-containing protein. (407 aa)
CGNCingulin (Predicted). (1204 aa)
SMAD3SMAD family member 3. (230 aa)
FSTL1Follistatin like 1. (425 aa)
ENSOCUP00000028580E2F_TDP domain-containing protein. (80 aa)
ARHGEF18Uncharacterized protein. (555 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (787 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1482 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (666 aa)
ENSOCUP00000030467Uncharacterized protein. (229 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (873 aa)
CHRDL2Chordin like 2. (637 aa)
CCNT2Cyclin T2. (690 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (291 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ENSOCUP00000034777Uncharacterized protein. (55 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (184 aa)
INHBAInhibin subunit beta A. (424 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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