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UBE2D1 UBE2D1 JAK2 JAK2 SYK SYK G1TZL0_RABIT G1TZL0_RABIT G1U1I7_RABIT G1U1I7_RABIT UBE2D2 UBE2D2 ENSOCUP00000030350 ENSOCUP00000030350 ENSOCUP00000030467 ENSOCUP00000030467 CSF3R CSF3R ELOC ELOC ENSOCUP00000034915 ENSOCUP00000034915 TYK2 TYK2 UBB UBB G1SG29_RABIT G1SG29_RABIT G1SIQ0_RABIT G1SIQ0_RABIT LYN LYN G1SK22_RABIT G1SK22_RABIT JAK1 JAK1 CSF3 CSF3 ELOB ELOB CUL5 CUL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2D1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SYKTyrosine-protein kinase. (630 aa)
G1TZL0_RABITUbiquitin-like domain-containing protein. (171 aa)
G1U1I7_RABITUncharacterized protein. (91 aa)
UBE2D2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (317 aa)
ENSOCUP00000030350Skp1_POZ domain-containing protein. (86 aa)
ENSOCUP00000030467Uncharacterized protein. (229 aa)
CSF3RColony stimulating factor 3 receptor. (1027 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
ENSOCUP00000034915Uncharacterized protein. (176 aa)
TYK2Non-specific protein-tyrosine kinase. (1065 aa)
UBBUbiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa)
G1SG29_RABITSkp1_POZ domain-containing protein. (72 aa)
G1SIQ0_RABITUBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa)
LYNTyrosine-protein kinase. (636 aa)
G1SK22_RABITUbiquitin-like domain-containing protein. (188 aa)
JAK1Tyrosine-protein kinase. (1151 aa)
CSF3Colony stimulating factor 3. (204 aa)
ELOBElongin B. (118 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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