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| | CLCNKA | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. (869 aa) |
| | LOC100343047 | Ubiquitin-like domain-containing protein. (77 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1074 aa) |
| | ATP11B | Probable phospholipid-transporting ATPase IF; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Isoform 2/RFBP appears to play a role in the subnuclear trafficking of transcription factors with RING motifs; Belongs to the cation transport [...] (1216 aa) |
| | LOC100338755 | VWFA domain-containing protein. (940 aa) |
| | TSC22D1 | Uncharacterized protein. (144 aa) |
| | TRPM6 | Transient receptor potential cation channel subfamily M member 6. (2007 aa) |
| | LOC108176505 | Asp-B-Hydro_N domain-containing protein. (595 aa) |
| | SCNN1G | Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. (710 aa) |
| | ENSOCUP00000036970 | annotation not available (754 aa) |
| | ATP2B2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1111 aa) |
| | ENSOCUP00000037059 | Uncharacterized protein. (317 aa) |
| | FXYD3 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (174 aa) |
| | ORYCUNV1R1515-2 | Vomeronasal type-1 receptor. (301 aa) |
| | ENSOCUP00000038446 | Ubiquitin-like domain-containing protein. (87 aa) |
| | SGK1 | Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peri [...] (526 aa) |
| | CLCN1 | Chloride channel protein. (1013 aa) |
| | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1017 aa) |
| | ORYCUNV1R1526 | Vomeronasal type-1 receptor. (315 aa) |
| | TRPC4AP | Transient receptor potential cation channel subfamily C member 4 associated protein. (882 aa) |
| | MBNL3 | Muscleblind like splicing regulator 3. (393 aa) |
| | NEDD4L | NEDD4 like E3 ubiquitin protein ligase. (1239 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (312 aa) |
| | CLIC2 | Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa) |
| | LOC100345551 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1170 aa) |
| | ORYCUNV1R1614 | Vomeronasal type-1 receptor. (315 aa) |
| | ATP2C1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (949 aa) |
| | ENSOCUP00000040138 | Anoctamin. (396 aa) |
| | ANO2-2 | Uncharacterized protein. (87 aa) |
| | MBNL1 | Muscleblind like splicing regulator 1. (434 aa) |
| | UNC79 | Uncharacterized protein. (130 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1822 aa) |
| | ORYCUNV1R1622 | Vomeronasal type-1 receptor. (283 aa) |
| | TRPM1 | Transient receptor potential cation channel subfamily M member 1. (1743 aa) |
| | ATP9A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (703 aa) |
| | STOML1 | PHB domain-containing protein. (701 aa) |
| | ANO10 | Anoctamin. (660 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (641 aa) |
| | REEP2 | Receptor expression-enhancing protein. (253 aa) |
| | NALCN | Sodium leak channel, non-selective. (1796 aa) |
| | ATP10D | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1396 aa) |
| | PMFBP1 | Polyamine modulated factor 1 binding protein 1. (881 aa) |
| | TRPC5 | Short transient receptor potential channel 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. (974 aa) |
| | MCOLN2 | Mucolipin 2. (566 aa) |
| | MCOLN3 | Mucolipin 3. (582 aa) |
| | ATP8B1 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1251 aa) |
| | SLC9C1 | Solute carrier family 9 member C1. (1151 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | TPCN3 | Uncharacterized protein. (766 aa) |
| | CASQ2 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (486 aa) |
| | G1T1C8_RABIT | Uncharacterized protein. (114 aa) |
| | G1T1E8_RABIT | Uncharacterized protein. (74 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase. (508 aa) |
| | WNK3 | WNK lysine deficient protein kinase 3. (1793 aa) |
| | MCOLN1 | Mucolipin 1. (578 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (670 aa) |
| | ATP6V0D1 | ATPase H+ transporting V0 subunit d1. (541 aa) |
| | SLN | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). (31 aa) |
| | TRPV3 | Transient receptor potential cation channel subfamily V member 3. (768 aa) |
| | TRPV1 | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Ac [...] (842 aa) |
| | TRPC4 | Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa) |
| | ALPK2 | Alpha kinase 2. (2095 aa) |
| | TSC22D3 | TSC22 domain family member 3. (203 aa) |
| | BEST4 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (469 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa) |
| | ASIC2 | Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (512 aa) |
| | PLN | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). (52 aa) |
| | SLC17A4 | Solute carrier family 17 member 4. (489 aa) |
| | BEST1 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (582 aa) |
| | ATP6AP1L | Uncharacterized protein. (367 aa) |
| | ATP6V1F | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa) |
| | ATP7A | ATPase copper transporting alpha. (1499 aa) |
| | ATP6V0E2 | V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa) |
| | ATP8A2 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1148 aa) |
| | SLC9C2 | Solute carrier family 9 member C2 (putative). (1113 aa) |
| | LOC100353613 | VWFA domain-containing protein. (871 aa) |
| | SRI | Uncharacterized protein. (422 aa) |
| | ATP13A4 | Cation_ATPase_N domain-containing protein. (615 aa) |
| | WNK4 | WNK lysine deficient protein kinase 4. (1266 aa) |
| | OSTM1 | Uncharacterized protein. (331 aa) |
| | TSC22D2 | TSC22 domain family member 2. (789 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | G1TBF4_RABIT | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (523 aa) |
| | WWC2 | WW and C2 domain containing 2. (1082 aa) |
| | PDZD11 | PDZ domain-containing protein. (140 aa) |
| | CLCN5 | H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). (816 aa) |
| | ZC3H10 | Zinc finger CCCH-type containing 10. (436 aa) |
| | ATP6AP1 | Uncharacterized protein. (470 aa) |
| | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha. (1027 aa) |
| | TRPC1 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. (793 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (469 aa) |
| | ANO3 | Anoctamin. (981 aa) |
| | ATP8A1 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1164 aa) |
| | ORYCUNV1R1562 | Vomeronasal type-1 receptor. (315 aa) |
| | ORYCUNV1R1644 | Vomeronasal type-1 receptor. (283 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. (491 aa) |
| | ATP6V1E2 | ATPase H+ transporting V1 subunit E2. (208 aa) |
| | BEST2 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (518 aa) |
| | ORYCUNV1R1665 | Vomeronasal type-1 receptor. (300 aa) |
| | STOML3 | Stomatin like 3. (290 aa) |
| | G1TP34_RABIT | Protein kinase domain-containing protein. (360 aa) |
| | ASIC4 | Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (512 aa) |
| | TMEM177 | Transmembrane protein 177. (311 aa) |
| | TRPA1 | Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa) |
| | ATP4B | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. (291 aa) |
| | LOC100356727 | Chloride channel protein. (760 aa) |
| | CCDC103 | Coiled-coil domain containing 103. (242 aa) |
| | FXYD1 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. (119 aa) |
| | ATP6V1G2 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa) |
| | G1TZL0_RABIT | Ubiquitin-like domain-containing protein. (171 aa) |
| | TRPC2 | Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (879 aa) |
| | TPCN1 | Two pore segment channel 1. (779 aa) |
| | LIM2 | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (251 aa) |
| | TSC22D4 | TSC22 domain family member 4. (450 aa) |
| | ASPHD1 | Asp_Arg_Hydrox domain-containing protein. (109 aa) |
| | TRPC3 | Transient receptor potential cation channel subfamily C member 3. (991 aa) |
| | REEP3 | Receptor expression-enhancing protein. (255 aa) |
| | TRPC6 | Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (929 aa) |
| | ATP4A | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1030 aa) |
| | BEST3 | Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (667 aa) |
| | UNC80 | Unc-80 homolog, NALCN channel complex subunit. (3255 aa) |
| | CASQ1 | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). (395 aa) |
| | TRDN | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). (706 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. (956 aa) |
| | RYR1 | Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] (4598 aa) |
| | ATP6V1G1 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (162 aa) |
| | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha. (1019 aa) |
| | ORYCUNV1R1513 | Vomeronasal type-1 receptor. (290 aa) |
| | ORYCUNV1R1569 | Vomeronasal type-1 receptor. (288 aa) |
| | ORYCUNV1R1661 | Vomeronasal type-1 receptor. (281 aa) |
| | U3KNC9_RABIT | Uncharacterized protein. (382 aa) |
| | ASIC3 | Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (546 aa) |
| | ORYCUNV1R1515 | Vomeronasal type-1 receptor. (301 aa) |
| | ORYCUNV1R1521 | Vomeronasal type-1 receptor. (315 aa) |
| | TRPM3 | Transient receptor potential cation channel subfamily M member 3. (1711 aa) |
| | ENSOCUP00000028320 | Uncharacterized protein. (212 aa) |
| | ATP6V1C2 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa) |
| | ATP10B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1432 aa) |
| | CNTD1 | Cyclin N-terminal domain containing 1. (331 aa) |
| | ATP11A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1065 aa) |
| | ENSOCUP00000042106 | PDZ domain-containing protein. (108 aa) |
| | ATP8B2 | PhoLip_ATPase_N domain-containing protein. (386 aa) |
| | ASPHD2 | Aspartate beta-hydroxylase domain containing 2. (532 aa) |
| | ORYCUNV1R1518 | Vomeronasal type-1 receptor. (315 aa) |
| | ATP7B | ATPase copper transporting beta. (1465 aa) |
| | ENSOCUP00000044498 | Ribosomal_L40e domain-containing protein. (152 aa) |
| | ATP11C | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1132 aa) |
| | RYR3 | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers [...] (4876 aa) |
| | FXYD5 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (241 aa) |
| | ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha. (964 aa) |
| | LOC100356734 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1283 aa) |
| | ENSOCUP00000046835 | Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (564 aa) |
| | ANO5 | Anoctamin. (1040 aa) |
| | FXYD6 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (139 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (738 aa) |
| | LOC103349229 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa) |
| | ENSOCUP00000047714 | Ubiquitin-like domain-containing protein. (71 aa) |
| | TRPM8 | Transient receptor potential cation channel subfamily M member 8. (1171 aa) |
| | ATP12A | Potassium-transporting ATPase alpha chain 2; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1080 aa) |
| | ENSOCUP00000048240 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (135 aa) |
| | ATP2B1 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa) |
| | ATP6V1C1 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (387 aa) |
| | CAMK2G | Protein kinase domain-containing protein. (592 aa) |
| | ATP2B3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1245 aa) |
| | ATP6V1G3 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (274 aa) |
| | ATP6V1B2 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (877 aa) |
| | UBB | Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa) |
| | ASIC5 | Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (502 aa) |
| | GIGYF2 | GRB10 interacting GYF protein 2. (1287 aa) |
| | REEP4 | Uncharacterized protein. (485 aa) |
| | RYR2 | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa) |
| | GIGYF1 | GRB10 interacting GYF protein 1. (1040 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). (290 aa) |
| | CUTC | CutC copper transporter. (273 aa) |
| | G1SJA2_RABIT | Anoctamin. (745 aa) |
| | LOC100352679 | VWFA domain-containing protein. (904 aa) |
| | G1SK22_RABIT | Ubiquitin-like domain-containing protein. (188 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (679 aa) |
| | TTYH3 | Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (780 aa) |
| | SLC17A2 | Solute carrier family 17 member 2. (506 aa) |
| | BSND | Uncharacterized protein. (320 aa) |
| | CLCA2 | Chloride channel accessory 2. (940 aa) |
| | CLCA1 | Chloride channel accessory 1. (911 aa) |
| | TRPC7 | Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (861 aa) |
| | MKI67 | FHA domain-containing protein. (3098 aa) |
| | SLC9B2 | Solute carrier family 9 member B2. (533 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2. (817 aa) |
| | ABI3BP | ABI family member 3 binding protein. (1763 aa) |
| | SLC9B1 | Solute carrier family 9 member B1. (513 aa) |
| | STOM | Stomatin. (284 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (283 aa) |
| | ATP8B4 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1169 aa) |
| | ANO6 | Anoctamin. (1003 aa) |
| | ALPK3 | Alpha kinase 3. (1548 aa) |
| | ATP6V0E1 | V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) |
| | ATP10A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1506 aa) |
| | ATP6V1A | ATPase H+ transporting V1 subunit A. (585 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa) |
| | FXYD4 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (90 aa) |
| | ANO2 | Anoctamin. (676 aa) |
| | ATP6V1E1 | ATPase H+ transporting V1 subunit E1. (226 aa) |
| | CLCN2 | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity). (898 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (265 aa) |
| | CLCN6 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 6/CLCN6 subfamily. (870 aa) |
| | TRPV6 | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (699 aa) |
| | TRPV5 | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric con [...] (730 aa) |
| | TTYH2 | Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (505 aa) |
| | SDR42E2 | Short chain dehydrogenase/reductase family 42E, member 2. (422 aa) |
| | CLCN3 | H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity); Belongs to the chloride channel (TC 2.A.49) family. ClC- 3/CLCN3 subfamily. (866 aa) |
| | ENSOCUP00000029750 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (907 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (628 aa) |
| | ENSOCUP00000030467 | Uncharacterized protein. (229 aa) |
| | ENSOCUP00000030568 | Cation_ATPase_N domain-containing protein. (178 aa) |
| | ENSOCUP00000030866 | Vomeronasal type-1 receptor. (290 aa) |
| | ATP2A1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. (984 aa) |
| | ENSOCUP00000031397 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (165 aa) |
| | ORYCUNV1R1672 | Vomeronasal type-1 receptor. (307 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1230 aa) |
| | ATP13A5 | Uncharacterized protein. (98 aa) |
| | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopath [...] (505 aa) |
| | ASIC1 | Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa) |
| | ATP9B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1140 aa) |
| | ATP6V1D | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). (259 aa) |
| | MBNL2 | Muscleblind like splicing regulator 2. (391 aa) |
| | WNK1 | WNK lysine deficient protein kinase 1. (2853 aa) |
| | ANO4 | Anoctamin. (1123 aa) |
| | ORYCUNV1R1531 | Vomeronasal type-1 receptor. (290 aa) |
