STRINGSTRING
RAG2 RAG2 IRF8 IRF8 FLT3 FLT3 FOXP1 FOXP1 PTEN PTEN CD69 CD69 IRF4 IRF4 FOXO3 FOXO3 PAX5 PAX5 LOC100357927 LOC100357927 FOXO1 FOXO1 H3F3B H3F3B CCND2 CCND2 IGLL1 IGLL1 H3C13 H3C13 SELL SELL VPREB1 VPREB1 LOC100345683 LOC100345683 H3-3A H3-3A LOC100344410 LOC100344410 CD3E CD3E RAG1 RAG1 G1TX56_RABIT G1TX56_RABIT AICDA AICDA CD5 CD5 VPREB1-2 VPREB1-2 IL4 IL4 G1TJR7_RABIT G1TJR7_RABIT BCR BCR PIK3C3 PIK3C3 CD86 CD86 BCL2 BCL2 CD19 CD19 PLEK PLEK IL7 IL7 FOXO4 FOXO4 ENSOCUP00000042583 ENSOCUP00000042583 PLEK2 PLEK2 GAPDH GAPDH CD9 CD9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
IRF8Interferon regulatory factor 8. (455 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FOXP1Fork-head domain-containing protein. (714 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CD69CD69 molecule. (201 aa)
IRF4Interferon regulatory factor 4. (451 aa)
FOXO3Fork-head domain-containing protein. (675 aa)
PAX5Paired box 5. (371 aa)
LOC100357927Histone domain-containing protein. (136 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
IGLL1Lambda5. (208 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (376 aa)
VPREB1Ig-like domain-containing protein. (147 aa)
LOC100345683Histone H3; Belongs to the histone H3 family. (136 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
LOC100344410Histone domain-containing protein. (136 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (201 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
G1TX56_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
AICDAActivation induced cytidine deaminase. (198 aa)
CD5Uncharacterized protein. (488 aa)
VPREB1-2Ig-like domain-containing protein. (147 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
G1TJR7_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
CD86T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
CD19CD19 molecule. (573 aa)
PLEKPleckstrin. (350 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
FOXO4Forkhead box O4. (503 aa)
ENSOCUP00000042583Histone H3; Belongs to the histone H3 family. (115 aa)
PLEK2Pleckstrin 2. (354 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
CD9Tetraspanin. (385 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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