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CUL2 | Cullin 2; Belongs to the cullin family. (745 aa) | ||||
DYRK1A | Dual-specificity tyrosine-phosphorylation-regulated kinase 1A. (829 aa) | ||||
CUL3 | Cullin 3; Belongs to the cullin family. (771 aa) | ||||
CUL1 | Cullin 1; Belongs to the cullin family. (775 aa) | ||||
NEDD8 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa) |