20 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)
	UBL3	Ubiquitin-like protein. (117 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	FBXO28	F-box protein 28. (368 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	FBXW7	F-box and WD repeat domain containing 7. (780 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	SKP2	F-box domain-containing protein. (435 aa)
	FBXO4	F-box protein 4. (387 aa)
	CUL5	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
	FBXO11	F-box protein 11. (842 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	CCNA1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
	FBXO45	F-box protein 45. (286 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (424 aa)
	SKP1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	PXDN	Peroxidasin. (1411 aa)
	FBXO9	F-box protein 9. (453 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNA1	CCNA2	ENSOCUP00000013635	ENSOCUP00000020057	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin A2; Belongs to the cyclin family.	0.944
CCNA1	CDK2	ENSOCUP00000013635	ENSOCUP00000034758	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.999
CCNA1	CUL1	ENSOCUP00000013635	ENSOCUP00000002198	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cullin 1; Belongs to the cullin family.	0.875
CCNA1	CUL2	ENSOCUP00000013635	ENSOCUP00000012675	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cullin 2; Belongs to the cullin family.	0.400
CCNA1	CUL3	ENSOCUP00000013635	ENSOCUP00000031324	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cullin 3; Belongs to the cullin family.	0.696
CCNA1	NEDD8	ENSOCUP00000013635	ENSOCUP00000002526	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.621
CCNA1	PLK1	ENSOCUP00000013635	ENSOCUP00000007325	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Serine/threonine-protein kinase PLK.	0.870
CCNA1	PXDN	ENSOCUP00000013635	ENSOCUP00000022906	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peroxidasin.	0.707
CCNA1	PXDNL	ENSOCUP00000013635	ENSOCUP00000004823	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peroxidasin like.	0.707
CCNA1	SKP1	ENSOCUP00000013635	ENSOCUP00000020468	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.887
CCNA1	SKP2	ENSOCUP00000013635	ENSOCUP00000007901	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	F-box domain-containing protein.	0.987
CCNA2	CCNA1	ENSOCUP00000020057	ENSOCUP00000013635	Cyclin A2; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.944
CCNA2	CDK2	ENSOCUP00000020057	ENSOCUP00000034758	Cyclin A2; Belongs to the cyclin family.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.999
CCNA2	CUL1	ENSOCUP00000020057	ENSOCUP00000002198	Cyclin A2; Belongs to the cyclin family.	Cullin 1; Belongs to the cullin family.	0.923
CCNA2	CUL2	ENSOCUP00000020057	ENSOCUP00000012675	Cyclin A2; Belongs to the cyclin family.	Cullin 2; Belongs to the cullin family.	0.409
CCNA2	CUL3	ENSOCUP00000020057	ENSOCUP00000031324	Cyclin A2; Belongs to the cyclin family.	Cullin 3; Belongs to the cullin family.	0.699
CCNA2	NEDD8	ENSOCUP00000020057	ENSOCUP00000002526	Cyclin A2; Belongs to the cyclin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.715
CCNA2	PLK1	ENSOCUP00000020057	ENSOCUP00000007325	Cyclin A2; Belongs to the cyclin family.	Serine/threonine-protein kinase PLK.	0.917
CCNA2	PXDN	ENSOCUP00000020057	ENSOCUP00000022906	Cyclin A2; Belongs to the cyclin family.	Peroxidasin.	0.735
CCNA2	PXDNL	ENSOCUP00000020057	ENSOCUP00000004823	Cyclin A2; Belongs to the cyclin family.	Peroxidasin like.	0.735