STRINGSTRING
DDB1 DDB1 CUL4B CUL4B TRPC4AP TRPC4AP DCAF6 DCAF6 CUL3 CUL3 DCAF4 DCAF4 PXDN PXDN SKP1 SKP1 CUL2 CUL2 CUL5 CUL5 DCAF5 DCAF5 CUL4A CUL4A DCAF12 DCAF12 PXDNL PXDNL CUL1 CUL1 DDB2 DDB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB1Damage specific DNA binding protein 1. (1140 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (882 aa)
DCAF6Uncharacterized protein. (922 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
DCAF4WD_REPEATS_REGION domain-containing protein. (507 aa)
PXDNPeroxidasin. (1411 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
DCAF5DDB1 and CUL4 associated factor 5. (946 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
DCAF12DDB1 and CUL4 associated factor 12. (453 aa)
PXDNLPeroxidasin like. (1467 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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