(32 nodes) (2010) Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes. network (Oryctolagus cuniculus)

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Predicted Interactions

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Your Input:
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
	TMOD3	Uncharacterized protein. (352 aa)
	ACTC1	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
	PRKD3	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (986 aa)
	RYR2	Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa)
	MYBPC3	Myosin binding protein C, cardiac. (1250 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (477 aa)
	TMOD2	Tropomodulin 2. (378 aa)
	TTN	Uncharacterized protein. (569 aa)
	LOC103351595	Angiotensin-converting enzyme. (740 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	MYL3	Myosin light chain 3. (327 aa)
	MYL2	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (232 aa)
	ACE	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1284 aa)
	TMOD4	Tropomodulin 4 (Predicted). (345 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (870 aa)
	MYH7	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
	TNNT2	Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (341 aa)
	REN	Renin; Belongs to the peptidase A1 family. (389 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. (826 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	SRI	Uncharacterized protein. (422 aa)
	TPM1	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	JUN	BZIP domain-containing protein; Belongs to the bZIP family. (352 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSOCUP00000022251	ENSOCUP00000015275	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Angiotensin-converting enzyme.	0.523
ACE	AGT	ENSOCUP00000022251	ENSOCUP00000000417	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Angiotensinogen; Belongs to the serpin family.	0.979
ACE	EDN1	ENSOCUP00000022251	ENSOCUP00000011526	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.773
ACE	ENSOCUP00000037329	ENSOCUP00000022251	ENSOCUP00000037329	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	TGFb_propeptide domain-containing protein.	0.561
ACE	ENSOCUP00000044284	ENSOCUP00000022251	ENSOCUP00000044284	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	TGFb_propeptide domain-containing protein.	0.561
ACE	G1TC56_RABIT	ENSOCUP00000022251	ENSOCUP00000014344	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	TGFb_propeptide domain-containing protein.	0.553
ACE	HMGCR	ENSOCUP00000022251	ENSOCUP00000014975	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family.	0.644
ACE	IL6	ENSOCUP00000022251	ENSOCUP00000017266	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.740
ACE	JUN	ENSOCUP00000022251	ENSOCUP00000040325	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	BZIP domain-containing protein; Belongs to the bZIP family.	0.502
ACE	LOC103345451	ENSOCUP00000022251	ENSOCUP00000031740	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	TGFb_propeptide domain-containing protein.	0.561
ACE	NR3C2	ENSOCUP00000022251	ENSOCUP00000002724	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Nuclear receptor subfamily 3 group C member 2.	0.810
ACE	PRKACB	ENSOCUP00000022251	ENSOCUP00000043583	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.454
ACE	REN	ENSOCUP00000022251	ENSOCUP00000017597	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Renin; Belongs to the peptidase A1 family.	0.981
ACE2	ACE	ENSOCUP00000015275	ENSOCUP00000022251	Angiotensin-converting enzyme.	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	0.523
ACE2	AGT	ENSOCUP00000015275	ENSOCUP00000000417	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.985
ACE2	EDN1	ENSOCUP00000015275	ENSOCUP00000011526	Angiotensin-converting enzyme.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.765
ACE2	ENSOCUP00000037329	ENSOCUP00000015275	ENSOCUP00000037329	Angiotensin-converting enzyme.	TGFb_propeptide domain-containing protein.	0.582
ACE2	ENSOCUP00000044284	ENSOCUP00000015275	ENSOCUP00000044284	Angiotensin-converting enzyme.	TGFb_propeptide domain-containing protein.	0.582
ACE2	G1TC56_RABIT	ENSOCUP00000015275	ENSOCUP00000014344	Angiotensin-converting enzyme.	TGFb_propeptide domain-containing protein.	0.569
ACE2	HMGCR	ENSOCUP00000015275	ENSOCUP00000014975	Angiotensin-converting enzyme.	3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family.	0.620