(27 nodes) (2010) Insights into the biology of IRES elements through riboproteomic approaches. network (Oryctolagus cuniculus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	RABIF	RAB interacting factor. (123 aa)
	HNRNPD	Heterogeneous nuclear ribonucleoprotein D. (286 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
	RACK1	WD_REPEATS_REGION domain-containing protein. (424 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (367 aa)
	DDX1	DEAD-box helicase 1. (740 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)
	EIF4A1	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. (406 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1183 aa)
	HNRNPA1	Uncharacterized protein. (371 aa)
	RRM1	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (745 aa)
	EIF4B	Eukaryotic translation initiation factor 4B. (631 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
	G1TJG6_RABIT	Glyceraldehyde-3-phosphate dehydrogenase. (305 aa)
	PCBP1	Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. (356 aa)
	NCL	Nucleolin. (721 aa)
	G1TYG1_RABIT	Glyceraldehyde-3-phosphate dehydrogenase. (369 aa)
	YBX1	Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (By similarity). Component of the CRD- mediated [...] (352 aa)
	HNRNPL	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	EIF5B	Eukaryotic translation initiation factor 5B. (1264 aa)
	DHX9	DExH-box helicase 9. (1298 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). (278 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. (1608 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (844 aa)
	EIF5	W2 domain-containing protein. (564 aa)
	GEMIN5	Gem nuclear organelle associated protein 5. (1518 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	EIF4A1	ENSOCUP00000010200	ENSOCUP00000008940	Apoptotic peptidase activating factor 1.	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	0.476
APAF1	G1TYG1_RABIT	ENSOCUP00000010200	ENSOCUP00000022125	Apoptotic peptidase activating factor 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.435
APAF1	GAPDH	ENSOCUP00000010200	ENSOCUP00000044112	Apoptotic peptidase activating factor 1.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.634
APAF1	HNRNPA1	ENSOCUP00000010200	ENSOCUP00000011492	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.411
APAF1	MYC	ENSOCUP00000010200	ENSOCUP00000012281	Apoptotic peptidase activating factor 1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.493
APAF1	RACK1	ENSOCUP00000010200	ENSOCUP00000002819	Apoptotic peptidase activating factor 1.	WD_REPEATS_REGION domain-containing protein.	0.427
DDX1	DHX9	ENSOCUP00000006066	ENSOCUP00000029909	DEAD-box helicase 1.	DExH-box helicase 9.	0.831
DDX1	EIF4B	ENSOCUP00000006066	ENSOCUP00000011602	DEAD-box helicase 1.	Eukaryotic translation initiation factor 4B.	0.474
DDX1	EIF4E	ENSOCUP00000006066	ENSOCUP00000032078	DEAD-box helicase 1.	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).	0.570
DDX1	EIF4G1	ENSOCUP00000006066	ENSOCUP00000032992	DEAD-box helicase 1.	Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.	0.548
DDX1	GEMIN5	ENSOCUP00000006066	ENSOCUP00000047614	DEAD-box helicase 1.	Gem nuclear organelle associated protein 5.	0.415
DDX1	HNRNPA1	ENSOCUP00000006066	ENSOCUP00000011492	DEAD-box helicase 1.	Uncharacterized protein.	0.594
DDX1	HNRNPK	ENSOCUP00000006066	ENSOCUP00000008932	DEAD-box helicase 1.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.738
DDX1	HNRNPL	ENSOCUP00000006066	ENSOCUP00000023948	DEAD-box helicase 1.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.400
DDX1	MYC	ENSOCUP00000006066	ENSOCUP00000012281	DEAD-box helicase 1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.449
DDX1	NCL	ENSOCUP00000006066	ENSOCUP00000021169	DEAD-box helicase 1.	Nucleolin.	0.516
DDX1	YBX1	ENSOCUP00000006066	ENSOCUP00000023346	DEAD-box helicase 1.	Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (By similarity). Component of the CRD- mediated [...]	0.426
DHX9	DDX1	ENSOCUP00000029909	ENSOCUP00000006066	DExH-box helicase 9.	DEAD-box helicase 1.	0.831
DHX9	EIF4A1	ENSOCUP00000029909	ENSOCUP00000008940	DExH-box helicase 9.	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	0.636
DHX9	EIF4B	ENSOCUP00000029909	ENSOCUP00000011602	DExH-box helicase 9.	Eukaryotic translation initiation factor 4B.	0.414