9 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UNC119	Unc-119 lipid binding chaperone. (145 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)
	ELOC	Elongin C; Belongs to the SKP1 family. (112 aa)
	KEAP1	Kelch like ECH associated protein 1. (631 aa)
	DDB1	Damage specific DNA binding protein 1. (1140 aa)
	PPIE	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL1	CUL3	ENSOCUP00000002198	ENSOCUP00000031324	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.887
CUL1	DDB1	ENSOCUP00000002198	ENSOCUP00000001429	Cullin 1; Belongs to the cullin family.	Damage specific DNA binding protein 1.	0.960
CUL1	ELOC	ENSOCUP00000002198	ENSOCUP00000033796	Cullin 1; Belongs to the cullin family.	Elongin C; Belongs to the SKP1 family.	0.829
CUL1	KEAP1	ENSOCUP00000002198	ENSOCUP00000044015	Cullin 1; Belongs to the cullin family.	Kelch like ECH associated protein 1.	0.858
CUL1	NEDD8	ENSOCUP00000002198	ENSOCUP00000002526	Cullin 1; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.999
CUL1	UBA3	ENSOCUP00000002198	ENSOCUP00000007065	Cullin 1; Belongs to the cullin family.	Ubiquitin like modifier activating enzyme 3.	0.955
CUL3	CUL1	ENSOCUP00000031324	ENSOCUP00000002198	Cullin 3; Belongs to the cullin family.	Cullin 1; Belongs to the cullin family.	0.887
CUL3	DDB1	ENSOCUP00000031324	ENSOCUP00000001429	Cullin 3; Belongs to the cullin family.	Damage specific DNA binding protein 1.	0.817
CUL3	ELOC	ENSOCUP00000031324	ENSOCUP00000033796	Cullin 3; Belongs to the cullin family.	Elongin C; Belongs to the SKP1 family.	0.809
CUL3	KEAP1	ENSOCUP00000031324	ENSOCUP00000044015	Cullin 3; Belongs to the cullin family.	Kelch like ECH associated protein 1.	0.999
CUL3	NEDD8	ENSOCUP00000031324	ENSOCUP00000002526	Cullin 3; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.995
CUL3	UBA3	ENSOCUP00000031324	ENSOCUP00000007065	Cullin 3; Belongs to the cullin family.	Ubiquitin like modifier activating enzyme 3.	0.934
DDB1	CUL1	ENSOCUP00000001429	ENSOCUP00000002198	Damage specific DNA binding protein 1.	Cullin 1; Belongs to the cullin family.	0.960
DDB1	CUL3	ENSOCUP00000001429	ENSOCUP00000031324	Damage specific DNA binding protein 1.	Cullin 3; Belongs to the cullin family.	0.817
DDB1	ELOC	ENSOCUP00000001429	ENSOCUP00000033796	Damage specific DNA binding protein 1.	Elongin C; Belongs to the SKP1 family.	0.658
DDB1	NEDD8	ENSOCUP00000001429	ENSOCUP00000002526	Damage specific DNA binding protein 1.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.971
DDB1	UBA3	ENSOCUP00000001429	ENSOCUP00000007065	Damage specific DNA binding protein 1.	Ubiquitin like modifier activating enzyme 3.	0.807
ELOC	CUL1	ENSOCUP00000033796	ENSOCUP00000002198	Elongin C; Belongs to the SKP1 family.	Cullin 1; Belongs to the cullin family.	0.829
ELOC	CUL3	ENSOCUP00000033796	ENSOCUP00000031324	Elongin C; Belongs to the SKP1 family.	Cullin 3; Belongs to the cullin family.	0.809
ELOC	DDB1	ENSOCUP00000033796	ENSOCUP00000001429	Elongin C; Belongs to the SKP1 family.	Damage specific DNA binding protein 1.	0.658