16 items (Oryctolagus cuniculus) - STRING interaction network

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	DDB1	Damage specific DNA binding protein 1. (1140 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)
	UBE2R2	Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
	PXDN	Peroxidasin. (1411 aa)
	SKP1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
	CDT1	Chromatin licensing and DNA replication factor 1. (365 aa)
	CCL2	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (901 aa)
	SKP2	F-box domain-containing protein. (435 aa)
	UBA1	Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	CAND1	Cullin associated and neddylation dissociated 1. (1207 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAND1	CDT1	ENSOCUP00000004347	ENSOCUP00000015721	Cullin associated and neddylation dissociated 1.	Chromatin licensing and DNA replication factor 1.	0.460
CAND1	CUL1	ENSOCUP00000004347	ENSOCUP00000002198	Cullin associated and neddylation dissociated 1.	Cullin 1; Belongs to the cullin family.	0.999
CAND1	CUL2	ENSOCUP00000004347	ENSOCUP00000012675	Cullin associated and neddylation dissociated 1.	Cullin 2; Belongs to the cullin family.	0.927
CAND1	CUL3	ENSOCUP00000004347	ENSOCUP00000031324	Cullin associated and neddylation dissociated 1.	Cullin 3; Belongs to the cullin family.	0.946
CAND1	CUL4B	ENSOCUP00000004347	ENSOCUP00000040452	Cullin associated and neddylation dissociated 1.	Cullin 4B; Belongs to the cullin family.	0.965
CAND1	DDB1	ENSOCUP00000004347	ENSOCUP00000001429	Cullin associated and neddylation dissociated 1.	Damage specific DNA binding protein 1.	0.857
CAND1	NEDD8	ENSOCUP00000004347	ENSOCUP00000002526	Cullin associated and neddylation dissociated 1.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.943
CAND1	SKP1	ENSOCUP00000004347	ENSOCUP00000020468	Cullin associated and neddylation dissociated 1.	Uncharacterized protein; Belongs to the SKP1 family.	0.849
CAND1	SKP2	ENSOCUP00000004347	ENSOCUP00000007901	Cullin associated and neddylation dissociated 1.	F-box domain-containing protein.	0.736
CAND1	UBA1	ENSOCUP00000004347	ENSOCUP00000007237	Cullin associated and neddylation dissociated 1.	Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).	0.568
CCL2	INS	ENSOCUP00000015636	ENSOCUP00000020463	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.772
CCL2	PXDN	ENSOCUP00000015636	ENSOCUP00000022906	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Peroxidasin.	0.767
CCL2	PXDNL	ENSOCUP00000015636	ENSOCUP00000004823	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Peroxidasin like.	0.764
CDT1	CAND1	ENSOCUP00000015721	ENSOCUP00000004347	Chromatin licensing and DNA replication factor 1.	Cullin associated and neddylation dissociated 1.	0.460
CDT1	CUL1	ENSOCUP00000015721	ENSOCUP00000002198	Chromatin licensing and DNA replication factor 1.	Cullin 1; Belongs to the cullin family.	0.800
CDT1	CUL2	ENSOCUP00000015721	ENSOCUP00000012675	Chromatin licensing and DNA replication factor 1.	Cullin 2; Belongs to the cullin family.	0.572
CDT1	CUL3	ENSOCUP00000015721	ENSOCUP00000031324	Chromatin licensing and DNA replication factor 1.	Cullin 3; Belongs to the cullin family.	0.622
CDT1	CUL4B	ENSOCUP00000015721	ENSOCUP00000040452	Chromatin licensing and DNA replication factor 1.	Cullin 4B; Belongs to the cullin family.	0.884
CDT1	DDB1	ENSOCUP00000015721	ENSOCUP00000001429	Chromatin licensing and DNA replication factor 1.	Damage specific DNA binding protein 1.	0.940
CDT1	NEDD8	ENSOCUP00000015721	ENSOCUP00000002526	Chromatin licensing and DNA replication factor 1.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.844