node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANPEP | CD19 | ENSOCUP00000015166 | ENSOCUP00000036537 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | CD19 molecule. | 0.747 |
ANPEP | CD34 | ENSOCUP00000015166 | ENSOCUP00000032705 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | CD34 molecule. | 0.863 |
ANPEP | CD38 | ENSOCUP00000015166 | ENSOCUP00000040603 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | 0.660 |
ANPEP | CD4 | ENSOCUP00000015166 | ENSOCUP00000030708 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.607 |
ANPEP | CD44 | ENSOCUP00000015166 | ENSOCUP00000048202 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | CD44 molecule (Indian blood group). | 0.827 |
ANPEP | KIT | ENSOCUP00000015166 | ENSOCUP00000034895 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.707 |
ANPEP | MME | ENSOCUP00000015166 | ENSOCUP00000041310 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.837 |
ANPEP | MPO | ENSOCUP00000015166 | ENSOCUP00000043679 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] | Myeloperoxidase. | 0.494 |
BLNK | CD19 | ENSOCUP00000002488 | ENSOCUP00000036537 | B cell linker. | CD19 molecule. | 0.906 |
BLNK | CD4 | ENSOCUP00000002488 | ENSOCUP00000030708 | B cell linker. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.539 |
BLNK | EBF1 | ENSOCUP00000002488 | ENSOCUP00000007763 | B cell linker. | EBF transcription factor 1. | 0.410 |
BLNK | IGHM-2 | ENSOCUP00000002488 | ENSOCUP00000018495 | B cell linker. | Ig-like domain-containing protein. | 0.494 |
BLNK | IGHM-3 | ENSOCUP00000002488 | ENSOCUP00000025645 | B cell linker. | Ig-like domain-containing protein. | 0.495 |
BLNK | IRF4 | ENSOCUP00000002488 | ENSOCUP00000008085 | B cell linker. | Interferon regulatory factor 4. | 0.520 |
BLNK | MS4A1 | ENSOCUP00000002488 | ENSOCUP00000006862 | B cell linker. | Membrane spanning 4-domains A1. | 0.488 |
BLNK | PAX5 | ENSOCUP00000002488 | ENSOCUP00000010574 | B cell linker. | Paired box 5. | 0.581 |
BLNK | SPIB | ENSOCUP00000002488 | ENSOCUP00000017492 | B cell linker. | ETS domain-containing protein. | 0.567 |
CCR6 | CD19 | ENSOCUP00000022718 | ENSOCUP00000036537 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | CD19 molecule. | 0.823 |
CCR6 | CD38 | ENSOCUP00000022718 | ENSOCUP00000040603 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | 0.667 |
CCR6 | CD4 | ENSOCUP00000022718 | ENSOCUP00000030708 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.858 |