14 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	JUN	BZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (268 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (172 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	MAOB	Amine oxidase. (530 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	SMAD3	SMAD family member 3. (230 aa)
	PARK2	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (394 aa)
	SMAD7	Mothers against decapentaplegic homolog. (549 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	ACVR2A	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR2A	JAG1	ENSOCUP00000014096	ENSOCUP00000002511	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.592
ACVR2A	SMAD3	ENSOCUP00000014096	ENSOCUP00000027151	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	SMAD family member 3.	0.987
ACVR2A	SMAD4	ENSOCUP00000014096	ENSOCUP00000003411	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.961
ACVR2A	SMAD7	ENSOCUP00000014096	ENSOCUP00000018353	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.804
COMT	MAOB	ENSOCUP00000048218	ENSOCUP00000036753	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Amine oxidase.	0.990
COMT	SNCA	ENSOCUP00000048218	ENSOCUP00000039624	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Alpha-synuclein; Belongs to the synuclein family.	0.493
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	G1TC56_RABIT	ENSOCUP00000037329	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.429
ENSOCUP00000037329	JAG1	ENSOCUP00000037329	ENSOCUP00000002511	TGFb_propeptide domain-containing protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
ENSOCUP00000037329	JUN	ENSOCUP00000037329	ENSOCUP00000040325	TGFb_propeptide domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.606
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000037329	SMAD3	ENSOCUP00000037329	ENSOCUP00000027151	TGFb_propeptide domain-containing protein.	SMAD family member 3.	0.876
ENSOCUP00000037329	SMAD4	ENSOCUP00000037329	ENSOCUP00000003411	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.834
ENSOCUP00000037329	SMAD7	ENSOCUP00000037329	ENSOCUP00000018353	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.824
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	G1TC56_RABIT	ENSOCUP00000044284	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.543
ENSOCUP00000044284	JAG1	ENSOCUP00000044284	ENSOCUP00000002511	TGFb_propeptide domain-containing protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
ENSOCUP00000044284	JUN	ENSOCUP00000044284	ENSOCUP00000040325	TGFb_propeptide domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.606
ENSOCUP00000044284	SMAD3	ENSOCUP00000044284	ENSOCUP00000027151	TGFb_propeptide domain-containing protein.	SMAD family member 3.	0.876
ENSOCUP00000044284	SMAD4	ENSOCUP00000044284	ENSOCUP00000003411	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.834