8 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KCTD2	Uncharacterized protein. (64 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	TNFAIP1	TNF alpha induced protein 1. (316 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	UBL3	Ubiquitin-like protein. (117 aa)
	KCTD5	Potassium channel tetramerization domain containing 5. (239 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL1	CUL2	ENSOCUP00000002198	ENSOCUP00000012675	Cullin 1; Belongs to the cullin family.	Cullin 2; Belongs to the cullin family.	0.742
CUL1	CUL3	ENSOCUP00000002198	ENSOCUP00000031324	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.887
CUL1	KCTD2	ENSOCUP00000002198	ENSOCUP00000024802	Cullin 1; Belongs to the cullin family.	Uncharacterized protein.	0.462
CUL1	KCTD5	ENSOCUP00000002198	ENSOCUP00000035228	Cullin 1; Belongs to the cullin family.	Potassium channel tetramerization domain containing 5.	0.717
CUL1	NEDD8	ENSOCUP00000002198	ENSOCUP00000002526	Cullin 1; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.999
CUL2	CUL1	ENSOCUP00000012675	ENSOCUP00000002198	Cullin 2; Belongs to the cullin family.	Cullin 1; Belongs to the cullin family.	0.742
CUL2	CUL3	ENSOCUP00000012675	ENSOCUP00000031324	Cullin 2; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.936
CUL2	NEDD8	ENSOCUP00000012675	ENSOCUP00000002526	Cullin 2; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.994
CUL3	CUL1	ENSOCUP00000031324	ENSOCUP00000002198	Cullin 3; Belongs to the cullin family.	Cullin 1; Belongs to the cullin family.	0.887
CUL3	CUL2	ENSOCUP00000031324	ENSOCUP00000012675	Cullin 3; Belongs to the cullin family.	Cullin 2; Belongs to the cullin family.	0.936
CUL3	KCTD2	ENSOCUP00000031324	ENSOCUP00000024802	Cullin 3; Belongs to the cullin family.	Uncharacterized protein.	0.712
CUL3	KCTD5	ENSOCUP00000031324	ENSOCUP00000035228	Cullin 3; Belongs to the cullin family.	Potassium channel tetramerization domain containing 5.	0.987
CUL3	NEDD8	ENSOCUP00000031324	ENSOCUP00000002526	Cullin 3; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.995
CUL3	TNFAIP1	ENSOCUP00000031324	ENSOCUP00000006713	Cullin 3; Belongs to the cullin family.	TNF alpha induced protein 1.	0.885
KCTD2	CUL1	ENSOCUP00000024802	ENSOCUP00000002198	Uncharacterized protein.	Cullin 1; Belongs to the cullin family.	0.462
KCTD2	CUL3	ENSOCUP00000024802	ENSOCUP00000031324	Uncharacterized protein.	Cullin 3; Belongs to the cullin family.	0.712
KCTD2	KCTD5	ENSOCUP00000024802	ENSOCUP00000035228	Uncharacterized protein.	Potassium channel tetramerization domain containing 5.	0.563
KCTD2	NEDD8	ENSOCUP00000024802	ENSOCUP00000002526	Uncharacterized protein.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.624
KCTD2	TNFAIP1	ENSOCUP00000024802	ENSOCUP00000006713	Uncharacterized protein.	TNF alpha induced protein 1.	0.565
KCTD5	CUL1	ENSOCUP00000035228	ENSOCUP00000002198	Potassium channel tetramerization domain containing 5.	Cullin 1; Belongs to the cullin family.	0.717