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CUL2 | Cullin 2; Belongs to the cullin family. (745 aa) | ||||
CUL5 | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa) | ||||
CUL1 | Cullin 1; Belongs to the cullin family. (775 aa) | ||||
CUL3 | Cullin 3; Belongs to the cullin family. (771 aa) | ||||
JADE1 | Jade family PHD finger 1. (876 aa) |