47 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
	LGALS8	Galectin. (381 aa)
	ENSOCUP00000031289	Uncharacterized protein. (151 aa)
	ITGAD	Integrin subunit alpha D; Belongs to the integrin alpha chain family. (1237 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	BIRC5	Uncharacterized protein. (164 aa)
	RHOQ	Uncharacterized protein. (356 aa)
	CD86	T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
	BCL2	BH4_2 domain-containing protein. (389 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	RHOB	Ras homolog family member B. (196 aa)
	KIF11	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1092 aa)
	ITGB2	Integrin beta. (1009 aa)
	TUBG1	Tubulin gamma 1; Belongs to the tubulin family. (652 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	LGALS3	Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage [...] (286 aa)
	ACTB	Uncharacterized protein. (357 aa)
	LOC100349824	Uncharacterized protein. (283 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1494 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	HLA-DQB2	Major histocompatibility complex, class II, DQ beta 1. (305 aa)
	CCL5	C-C motif chemokine. (91 aa)
	TLR2	TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	COL22A1	VWFA domain-containing protein. (1299 aa)
	IL15	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
	CD209	C-type lectin domain-containing protein. (239 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1637 aa)
	RHOA	Ras homolog family member A. (193 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
	CCL13	C-C motif chemokine. (95 aa)
	COL3A1	Collagen type III alpha 1 chain. (1462 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	RHOG	Ras homolog family member G. (191 aa)
	CCL2	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
	TLR1	TIR domain-containing protein; Belongs to the Toll-like receptor family. (796 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
	CCR5	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
	LGALS1	Galectin. (134 aa)
	TUBA4A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	IL17RA	Interleukin 17 receptor A. (860 aa)
	PXDN	Peroxidasin. (1411 aa)
	CDC42-2	Uncharacterized protein. (222 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1030 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	BCL2	ENSOCUP00000045964	ENSOCUP00000036189	Uncharacterized protein.	BH4_2 domain-containing protein.	0.492
ACTB	CCL2	ENSOCUP00000045964	ENSOCUP00000015636	Uncharacterized protein.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.540
ACTB	CDC42-2	ENSOCUP00000045964	ENSOCUP00000025997	Uncharacterized protein.	Uncharacterized protein.	0.939
ACTB	ENSOCUP00000031289	ENSOCUP00000045964	ENSOCUP00000031289	Uncharacterized protein.	Uncharacterized protein.	0.937
ACTB	ITGA5	ENSOCUP00000045964	ENSOCUP00000011512	Uncharacterized protein.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.926
ACTB	ITGA7	ENSOCUP00000045964	ENSOCUP00000028604	Uncharacterized protein.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.920
ACTB	LOC100349824	ENSOCUP00000045964	ENSOCUP00000046968	Uncharacterized protein.	Uncharacterized protein.	0.943
ACTB	PXDN	ENSOCUP00000045964	ENSOCUP00000022906	Uncharacterized protein.	Peroxidasin.	0.715
ACTB	PXDNL	ENSOCUP00000045964	ENSOCUP00000004823	Uncharacterized protein.	Peroxidasin like.	0.715
ACTB	RHOA	ENSOCUP00000045964	ENSOCUP00000011466	Uncharacterized protein.	Ras homolog family member A.	0.946
ACTB	TLR4	ENSOCUP00000045964	ENSOCUP00000001909	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.477
ACTB	TUBA4A	ENSOCUP00000045964	ENSOCUP00000019536	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.567
ACTB	TUBG1	ENSOCUP00000045964	ENSOCUP00000040129	Uncharacterized protein.	Tubulin gamma 1; Belongs to the tubulin family.	0.490
BAX	BCL2	ENSOCUP00000005553	ENSOCUP00000036189	BCL2 associated X, apoptosis regulator.	BH4_2 domain-containing protein.	0.998
BAX	PXDN	ENSOCUP00000005553	ENSOCUP00000022906	BCL2 associated X, apoptosis regulator.	Peroxidasin.	0.407
BAX	PXDNL	ENSOCUP00000005553	ENSOCUP00000004823	BCL2 associated X, apoptosis regulator.	Peroxidasin like.	0.400
BCL2	ACTB	ENSOCUP00000036189	ENSOCUP00000045964	BH4_2 domain-containing protein.	Uncharacterized protein.	0.492
BCL2	BAX	ENSOCUP00000036189	ENSOCUP00000005553	BH4_2 domain-containing protein.	BCL2 associated X, apoptosis regulator.	0.998
BCL2	BIRC5	ENSOCUP00000036189	ENSOCUP00000034425	BH4_2 domain-containing protein.	Uncharacterized protein.	0.676
BCL2	CCL2	ENSOCUP00000036189	ENSOCUP00000015636	BH4_2 domain-containing protein.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.612