STRINGSTRING
CSNK1D CSNK1D CUL1 CUL1 PXDNL PXDNL DSG1 DSG1 DSG3 DSG3 DSG2 DSG2 CUL4A CUL4A EGFR EGFR CUL5 CUL5 MYC MYC CUL2 CUL2 SKP1 SKP1 PXDN PXDN CUL3 CUL3 BRAF BRAF CSNK1A1 CSNK1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSNK1DCasein kinase I isoform delta. (429 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
PXDNLPeroxidasin like. (1467 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1093 aa)
DSG3Uncharacterized protein. (281 aa)
DSG2Desmoglein 2. (1119 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
PXDNPeroxidasin. (1411 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (378 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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