22 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX9	SRY-box transcription factor 9. (496 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SYCP3	Synaptonemal complex protein 3. (234 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	ACVR2A	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	POU5F1	POU domain protein. (360 aa)
	CHEK2	Checkpoint kinase 2. (538 aa)
	PIWIL1	Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
	NANOG	Homeobox domain-containing protein. (306 aa)
	CANX	Calnexin. (622 aa)
	LOC103345231	Cor1 domain-containing protein. (221 aa)
	U3KPL9_RABIT	Cor1 domain-containing protein. (260 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	CTNNB1	Catenin beta 1. (741 aa)
	TCF4	Transcription factor 4. (701 aa)
	RSPO1	Uncharacterized protein. (400 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR2A	NODAL	ENSOCUP00000014096	ENSOCUP00000007498	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.972
ACVR2A	SMAD2	ENSOCUP00000014096	ENSOCUP00000009717	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.990
ACVR2A	TGFB2	ENSOCUP00000014096	ENSOCUP00000004578	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.412
ACVR2A	TGFB3	ENSOCUP00000014096	ENSOCUP00000009817	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta 3.	0.479
ACVR2A	TGFBR2	ENSOCUP00000014096	ENSOCUP00000030537	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.400
ACVR2A	TGFBR3	ENSOCUP00000014096	ENSOCUP00000013829	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta receptor 3.	0.702
CTNNB1	NANOG	ENSOCUP00000032985	ENSOCUP00000022082	Catenin beta 1.	Homeobox domain-containing protein.	0.591
CTNNB1	POU5F1	ENSOCUP00000032985	ENSOCUP00000014745	Catenin beta 1.	POU domain protein.	0.805
CTNNB1	RSPO1	ENSOCUP00000032985	ENSOCUP00000038659	Catenin beta 1.	Uncharacterized protein.	0.540
CTNNB1	SMAD2	ENSOCUP00000032985	ENSOCUP00000009717	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.847
CTNNB1	SOX9	ENSOCUP00000032985	ENSOCUP00000010009	Catenin beta 1.	SRY-box transcription factor 9.	0.715
CTNNB1	TCF4	ENSOCUP00000032985	ENSOCUP00000036732	Catenin beta 1.	Transcription factor 4.	0.850
CTNNB1	TGFBR2	ENSOCUP00000032985	ENSOCUP00000030537	Catenin beta 1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.576
CTNNB1	WNT4	ENSOCUP00000032985	ENSOCUP00000020454	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.722
FGF9	NANOG	ENSOCUP00000000634	ENSOCUP00000022082	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox domain-containing protein.	0.605
FGF9	POU5F1	ENSOCUP00000000634	ENSOCUP00000014745	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	POU domain protein.	0.661
FGF9	RSPO1	ENSOCUP00000000634	ENSOCUP00000038659	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.448
FGF9	SMAD2	ENSOCUP00000000634	ENSOCUP00000009717	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Mothers against decapentaplegic homolog.	0.592
FGF9	SOX9	ENSOCUP00000000634	ENSOCUP00000010009	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.781
FGF9	WNT4	ENSOCUP00000000634	ENSOCUP00000020454	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.604