STRINGSTRING
ACTA1 ACTA1 WNT3A WNT3A ANGPT1 ANGPT1 MEF2C MEF2C SMAD5 SMAD5 FGF13 FGF13 PRKCB PRKCB PPARG PPARG ENSOCUP00000042583 ENSOCUP00000042583 FGF17 FGF17 FGF14 FGF14 JUN JUN FGF7 FGF7 NOTCH2 NOTCH2 GFAP GFAP FGF18 FGF18 ALG14 ALG14 CD34 CD34 HGF HGF WNT7A WNT7A G1TJR7_RABIT G1TJR7_RABIT WNT1 WNT1 NOTCH3 NOTCH3 CARM1 CARM1 SMTN SMTN MB MB MYF5 MYF5 BMP7 BMP7 G1TX56_RABIT G1TX56_RABIT IGF1 IGF1 INS INS BGLAP BGLAP GJA1 GJA1 WNT6 WNT6 LOC100344410 LOC100344410 H3-3A H3-3A LOC100345683 LOC100345683 FGF4 FGF4 FLT1 FLT1 H3C13 H3C13 PAX3 PAX3 FGF21 FGF21 POU5F1 POU5F1 HEY1 HEY1 H3F3B H3F3B MYC MYC FGF1 FGF1 LOC100357927 LOC100357927 MSTN MSTN FGF5 FGF5 MEF2D MEF2D SOX9 SOX9 MYOG MYOG BMP4 BMP4 FOXO3 FOXO3 CLDN4 CLDN4 FGF10 FGF10 G1SV95_RABIT G1SV95_RABIT FGF12 FGF12 FGF16 FGF16 ACTC1 ACTC1 PAX7 PAX7 KLF4 KLF4 TGFB2 TGFB2 CDX2 CDX2 FGF11 FGF11 BMP6 BMP6 FGF6 FGF6 CXCR4 CXCR4 TNNT3 TNNT3 FGF9 FGF9 HEYL HEYL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTA1Actin, alpha skeletal muscle. (369 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ANGPT1Angiopoietin 1. (551 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSOCUP00000042583Histone H3; Belongs to the histone H3 family. (115 aa)
FGF17Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
NOTCH2Notch receptor 2. (2481 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
ALG14Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (526 aa)
CD34CD34 molecule. (415 aa)
HGFHeptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes. (761 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
G1TJR7_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NOTCH3Notch receptor 3. (2262 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (556 aa)
SMTNSmoothelin. (943 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (106 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
G1TX56_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (356 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
LOC100344410Histone domain-containing protein. (136 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
LOC100345683Histone H3; Belongs to the histone H3 family. (136 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1479 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
PAX3Paired box 3. (484 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
POU5F1POU domain protein. (360 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC100357927Histone domain-containing protein. (136 aa)
MSTNMyostatin. (375 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
MEF2DMyocyte enhancer factor 2D. (517 aa)
SOX9SRY-box transcription factor 9. (496 aa)
MYOGMyogenin. (225 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
FOXO3Fork-head domain-containing protein. (675 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
PAX7Paired box 7. (476 aa)
KLF4Uncharacterized protein. (145 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDX2Caudal type homeobox 2. (314 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
BMP6Bone morphogenetic protein 6. (411 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TNNT3Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (202 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (301 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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