(17 nodes) (2013) RhoA modulates functional and physical interaction between ROCK1 and Erk12 in selenite-induced apoptosis of leukaemia cells. network (Oryctolagus cuniculus)

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Your Input:
	ANXA7	Annexin. (613 aa)
	MSN	FERM domain-containing protein. (577 aa)
	ANXA6	Annexin. (913 aa)
	RHOA	Ras homolog family member A. (193 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
	ANXA4	Annexin. (321 aa)
	ANXA5	Annexin. (321 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
	ANXA13	Annexin. (366 aa)
	ROCK1	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
	RDX	Radixin. (643 aa)
	ANXA3	Annexin. (323 aa)
	EZR	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa)
	JUN	BZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (466 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA13	CASP3	ENSOCUP00000030007	ENSOCUP00000036614	Annexin.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.823
ANXA13	CASP9	ENSOCUP00000030007	ENSOCUP00000047129	Annexin.	Caspase 9; Belongs to the peptidase C14A family.	0.706
ANXA13	EZR	ENSOCUP00000030007	ENSOCUP00000040029	Annexin.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.410
ANXA13	JUN	ENSOCUP00000030007	ENSOCUP00000040325	Annexin.	BZIP domain-containing protein; Belongs to the bZIP family.	0.431
ANXA13	MYC	ENSOCUP00000030007	ENSOCUP00000012281	Annexin.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.550
ANXA3	CASP3	ENSOCUP00000015360	ENSOCUP00000036614	Annexin.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.821
ANXA3	CASP9	ENSOCUP00000015360	ENSOCUP00000047129	Annexin.	Caspase 9; Belongs to the peptidase C14A family.	0.706
ANXA3	EZR	ENSOCUP00000015360	ENSOCUP00000040029	Annexin.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.430
ANXA3	JUN	ENSOCUP00000015360	ENSOCUP00000040325	Annexin.	BZIP domain-containing protein; Belongs to the bZIP family.	0.441
ANXA3	MYC	ENSOCUP00000015360	ENSOCUP00000012281	Annexin.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.548
ANXA4	CASP3	ENSOCUP00000013569	ENSOCUP00000036614	Annexin.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.820
ANXA4	CASP9	ENSOCUP00000013569	ENSOCUP00000047129	Annexin.	Caspase 9; Belongs to the peptidase C14A family.	0.705
ANXA4	EZR	ENSOCUP00000013569	ENSOCUP00000040029	Annexin.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.426
ANXA4	JUN	ENSOCUP00000013569	ENSOCUP00000040325	Annexin.	BZIP domain-containing protein; Belongs to the bZIP family.	0.435
ANXA4	MYC	ENSOCUP00000013569	ENSOCUP00000012281	Annexin.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.549
ANXA5	CASP3	ENSOCUP00000015253	ENSOCUP00000036614	Annexin.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.865
ANXA5	CASP9	ENSOCUP00000015253	ENSOCUP00000047129	Annexin.	Caspase 9; Belongs to the peptidase C14A family.	0.788
ANXA5	EZR	ENSOCUP00000015253	ENSOCUP00000040029	Annexin.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.442
ANXA5	JUN	ENSOCUP00000015253	ENSOCUP00000040325	Annexin.	BZIP domain-containing protein; Belongs to the bZIP family.	0.479
ANXA5	KIT	ENSOCUP00000015253	ENSOCUP00000034895	Annexin.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.484