(10 nodes) (2013) The Arctic AbetaPP mutation leads to Alzheimers disease pathology with highly variable topographic deposition of differentially truncated Abeta. network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (172 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
	PXDN	Peroxidasin. (1411 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (255 aa)
	SERPINA1	Alpha-1-antiproteinase F; Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin; Belongs to the serpin family. (458 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
	APP	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	CA4	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). (416 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	BACE1	ENSOCUP00000009130	ENSOCUP00000025190	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Beta-secretase 1; Belongs to the peptidase A1 family.	0.997
APP	CA4	ENSOCUP00000009130	ENSOCUP00000046147	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).	0.535
APP	CTSD	ENSOCUP00000009130	ENSOCUP00000020628	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.705
APP	GFAP	ENSOCUP00000009130	ENSOCUP00000034730	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.854
APP	PSEN1	ENSOCUP00000009130	ENSOCUP00000012504	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
APP	PXDN	ENSOCUP00000009130	ENSOCUP00000022906	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Peroxidasin.	0.771
APP	PXDNL	ENSOCUP00000009130	ENSOCUP00000004823	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Peroxidasin like.	0.768
APP	SNCA	ENSOCUP00000009130	ENSOCUP00000039624	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Alpha-synuclein; Belongs to the synuclein family.	0.967
BACE1	APP	ENSOCUP00000025190	ENSOCUP00000009130	Beta-secretase 1; Belongs to the peptidase A1 family.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.997
BACE1	CTSD	ENSOCUP00000025190	ENSOCUP00000020628	Beta-secretase 1; Belongs to the peptidase A1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.642
BACE1	GFAP	ENSOCUP00000025190	ENSOCUP00000034730	Beta-secretase 1; Belongs to the peptidase A1 family.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.660
BACE1	PSEN1	ENSOCUP00000025190	ENSOCUP00000012504	Beta-secretase 1; Belongs to the peptidase A1 family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.911
BACE1	PXDN	ENSOCUP00000025190	ENSOCUP00000022906	Beta-secretase 1; Belongs to the peptidase A1 family.	Peroxidasin.	0.592
BACE1	PXDNL	ENSOCUP00000025190	ENSOCUP00000004823	Beta-secretase 1; Belongs to the peptidase A1 family.	Peroxidasin like.	0.592
BACE1	SNCA	ENSOCUP00000025190	ENSOCUP00000039624	Beta-secretase 1; Belongs to the peptidase A1 family.	Alpha-synuclein; Belongs to the synuclein family.	0.578
CA4	APP	ENSOCUP00000046147	ENSOCUP00000009130	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.535
CA4	GFAP	ENSOCUP00000046147	ENSOCUP00000034730	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.580
CA4	PXDN	ENSOCUP00000046147	ENSOCUP00000022906	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).	Peroxidasin.	0.491
CA4	PXDNL	ENSOCUP00000046147	ENSOCUP00000004823	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).	Peroxidasin like.	0.491
CA4	SNCA	ENSOCUP00000046147	ENSOCUP00000039624	Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity).	Alpha-synuclein; Belongs to the synuclein family.	0.564