60 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TIAM2	DH domain-containing protein. (609 aa)
	FGD1	FYVE, RhoGEF and PH domain containing 1. (950 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1362 aa)
	IRF8	Interferon regulatory factor 8. (455 aa)
	LCP2	Lymphocyte cytosolic protein 2. (534 aa)
	SMTNL2	Smoothelin like 2. (568 aa)
	CD82	Tetraspanin. (260 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (830 aa)
	CCR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ALPL	Alkaline phosphatase. (558 aa)
	SYT13	Synaptotagmin 13. (425 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
	EBF1	EBF transcription factor 1. (591 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	IL7R	Interleukin 7 receptor. (458 aa)
	VCAM1	Uncharacterized protein. (828 aa)
	GRAP2	GRB2 related adaptor protein 2. (267 aa)
	PAX5	Paired box 5. (371 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
	PGK1	Phosphoglycerate kinase. (417 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (827 aa)
	SYK	Tyrosine-protein kinase. (630 aa)
	IGLL1	Lambda5. (208 aa)
	LOC100348124	Phosphoglycerate kinase. (452 aa)
	IGHM-2	Ig-like domain-containing protein. (167 aa)
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	RAG2	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
	TBP	TATA-box binding protein. (323 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
	GRB7	Growth factor receptor bound protein 7. (529 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
	CENPV	GFA domain-containing protein. (303 aa)
	CD5	Uncharacterized protein. (488 aa)
	CANX	Calnexin. (622 aa)
	IGHM-3	Ig-like domain-containing protein. (167 aa)
	CDC42-2	Uncharacterized protein. (222 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1192 aa)
	ICAM1	Intercellular adhesion molecule 1. (534 aa)
	ITGA9	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (597 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (574 aa)
	CD72	C-type lectin domain-containing protein. (410 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
	RASSF5	Ras association domain family member 5. (324 aa)
	CD40	Uncharacterized protein. (494 aa)
	CDH22	Uncharacterized protein. (465 aa)
	RHOQ	Uncharacterized protein. (356 aa)
	CD86	T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
	CD19	CD19 molecule. (573 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (287 aa)
	ABL1	Tyrosine-protein kinase. (1118 aa)
	CD38	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. (299 aa)
	CD22	CD22 molecule. (966 aa)
	PTPN6	Protein tyrosine phosphatase non-receptor type 6. (561 aa)
	PDCD1	Ig-like domain-containing protein. (367 aa)
	CD55	Uncharacterized protein. (430 aa)
	SLAMF6	Ig-like domain-containing protein. (387 aa)
	CDC42	Uncharacterized protein. (191 aa)
	CD44	CD44 molecule (Indian blood group). (761 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCR	ENSOCUP00000038489	ENSOCUP00000027066	Tyrosine-protein kinase.	BCR activator of RhoGEF and GTPase.	0.948
ABL1	CCND3	ENSOCUP00000038489	ENSOCUP00000038342	Tyrosine-protein kinase.	Cyclin D3; Belongs to the cyclin family.	0.415
ABL1	CDC42	ENSOCUP00000038489	ENSOCUP00000047724	Tyrosine-protein kinase.	Uncharacterized protein.	0.540
ABL1	CDC42-2	ENSOCUP00000038489	ENSOCUP00000025997	Tyrosine-protein kinase.	Uncharacterized protein.	0.538
ABL1	GRAP2	ENSOCUP00000038489	ENSOCUP00000010557	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.401
ABL1	IGHM-2	ENSOCUP00000038489	ENSOCUP00000018495	Tyrosine-protein kinase.	Ig-like domain-containing protein.	0.408
ABL1	IGHM-3	ENSOCUP00000038489	ENSOCUP00000025645	Tyrosine-protein kinase.	Ig-like domain-containing protein.	0.408
ABL1	PAX5	ENSOCUP00000038489	ENSOCUP00000010574	Tyrosine-protein kinase.	Paired box 5.	0.449
BCAR3	RHOQ	ENSOCUP00000013264	ENSOCUP00000034793	BCAR3 adaptor protein, NSP family member.	Uncharacterized protein.	0.426
BCR	ABL1	ENSOCUP00000027066	ENSOCUP00000038489	BCR activator of RhoGEF and GTPase.	Tyrosine-protein kinase.	0.948
BCR	CDC42	ENSOCUP00000027066	ENSOCUP00000047724	BCR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.539
BCR	CDC42-2	ENSOCUP00000027066	ENSOCUP00000025997	BCR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.539
BCR	RHOQ	ENSOCUP00000027066	ENSOCUP00000034793	BCR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.419
CANX	CD4	ENSOCUP00000025012	ENSOCUP00000030708	Calnexin.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.429
CANX	ITGB1	ENSOCUP00000025012	ENSOCUP00000003143	Calnexin.	Integrin beta; Belongs to the integrin beta chain family.	0.433
CANX	SYK	ENSOCUP00000025012	ENSOCUP00000015068	Calnexin.	Tyrosine-protein kinase.	0.402
CCND3	ABL1	ENSOCUP00000038342	ENSOCUP00000038489	Cyclin D3; Belongs to the cyclin family.	Tyrosine-protein kinase.	0.415
CCND3	HDAC5	ENSOCUP00000038342	ENSOCUP00000007421	Cyclin D3; Belongs to the cyclin family.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.453
CCND3	HDAC9	ENSOCUP00000038342	ENSOCUP00000012429	Cyclin D3; Belongs to the cyclin family.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.488
CCR2	CD19	ENSOCUP00000003173	ENSOCUP00000036537	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	CD19 molecule.	0.650