22 items (Oryctolagus cuniculus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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	IRF8	Interferon regulatory factor 8. (455 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	MPO	Myeloperoxidase. (725 aa)
	MME	Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
	CD22	CD22 molecule. (966 aa)
	CD38	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. (299 aa)
	CD1A	Ig-like domain-containing protein. (353 aa)
	CD19	CD19 molecule. (573 aa)
	BCL2	BH4_2 domain-containing protein. (389 aa)
	CD34	CD34 molecule. (415 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
	CD5	Uncharacterized protein. (488 aa)
	RAG2	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
	IGLL1	Lambda5. (208 aa)
	FOXN1	Forkhead box N1. (648 aa)
	LOC103351183	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
	PAX5	Paired box 5. (371 aa)
	ADA	Adenosine deaminase. (363 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	IRF7	Interferon regulatory factor 7. (438 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	CD4	ENSOCUP00000008708	ENSOCUP00000030708	Adenosine deaminase.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.409
BCL2	CD19	ENSOCUP00000036189	ENSOCUP00000036537	BH4_2 domain-containing protein.	CD19 molecule.	0.679
BCL2	CD22	ENSOCUP00000036189	ENSOCUP00000040726	BH4_2 domain-containing protein.	CD22 molecule.	0.519
BCL2	CD34	ENSOCUP00000036189	ENSOCUP00000032705	BH4_2 domain-containing protein.	CD34 molecule.	0.732
BCL2	CD38	ENSOCUP00000036189	ENSOCUP00000040603	BH4_2 domain-containing protein.	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.	0.592
BCL2	CD4	ENSOCUP00000036189	ENSOCUP00000030708	BH4_2 domain-containing protein.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.781
BCL2	CD5	ENSOCUP00000036189	ENSOCUP00000023266	BH4_2 domain-containing protein.	Uncharacterized protein.	0.719
BCL2	IRF4	ENSOCUP00000036189	ENSOCUP00000008085	BH4_2 domain-containing protein.	Interferon regulatory factor 4.	0.523
BCL2	LOC103351183	ENSOCUP00000036189	ENSOCUP00000011323	BH4_2 domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.532
BCL2	MME	ENSOCUP00000036189	ENSOCUP00000041310	BH4_2 domain-containing protein.	Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family.	0.689
BCL2	MPO	ENSOCUP00000036189	ENSOCUP00000043679	BH4_2 domain-containing protein.	Myeloperoxidase.	0.558
BCL2	PAX5	ENSOCUP00000036189	ENSOCUP00000010574	BH4_2 domain-containing protein.	Paired box 5.	0.541
BCL2	TP53	ENSOCUP00000036189	ENSOCUP00000000989	BH4_2 domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.994
CD19	BCL2	ENSOCUP00000036537	ENSOCUP00000036189	CD19 molecule.	BH4_2 domain-containing protein.	0.679
CD19	CD1A	ENSOCUP00000036537	ENSOCUP00000036769	CD19 molecule.	Ig-like domain-containing protein.	0.683
CD19	CD22	ENSOCUP00000036537	ENSOCUP00000040726	CD19 molecule.	CD22 molecule.	0.951
CD19	CD34	ENSOCUP00000036537	ENSOCUP00000032705	CD19 molecule.	CD34 molecule.	0.923
CD19	CD38	ENSOCUP00000036537	ENSOCUP00000040603	CD19 molecule.	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.	0.912
CD19	CD4	ENSOCUP00000036537	ENSOCUP00000030708	CD19 molecule.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.971
CD19	CD5	ENSOCUP00000036537	ENSOCUP00000023266	CD19 molecule.	Uncharacterized protein.	0.948