STRINGSTRING
GLI2 GLI2 VCL VCL CYLD CYLD PHLPP1 PHLPP1 CUL3 CUL3 TRAF6 TRAF6 PXDN PXDN SKP1 SKP1 CUL2 CUL2 MYC MYC MCL1 MCL1 TNFRSF11B TNFRSF11B CUL5 CUL5 CUL4A CUL4A TRAF5 TRAF5 NFATC1 NFATC1 TRAF1 TRAF1 PXDNL PXDNL TRAF3 TRAF3 CUL1 CUL1 TRAF4 TRAF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLI2GLI family zinc finger 2. (1575 aa)
VCLVinculin. (1241 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1569 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
PXDNPeroxidasin. (1411 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (352 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
NFATC1RHD domain-containing protein. (672 aa)
TRAF1TNF receptor-associated factor. (415 aa)
PXDNLPeroxidasin like. (1467 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
TRAF4TNF receptor-associated factor. (470 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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