STRINGSTRING
DDB1 DDB1 CUL7 CUL7 NAE1 NAE1 CUL4B CUL4B STAT1 STAT1 CDK6 CDK6 UBE2F UBE2F SUMO1 SUMO1 ELOC ELOC STAT4 STAT4 CUL3 CUL3 CD4 CD4 LOC100339305 LOC100339305 VHL VHL EME1 EME1 SAE1 SAE1 STAT5A STAT5A SMUG1 SMUG1 SKP1 SKP1 INS INS CDC34 CDC34 CCR5 CCR5 CRLS1 CRLS1 RAD50 RAD50 CDT1 CDT1 UBE2M UBE2M MRE11 MRE11 CUL2 CUL2 FBXO3 FBXO3 MYC MYC TOPBP1 TOPBP1 STAT3 STAT3 CUL5 CUL5 ELOB ELOB STAG2 STAG2 CUL4A CUL4A PLK1 PLK1 STAT6 STAT6 ATRX ATRX SLX4 SLX4 IRS1 IRS1 STAT5B STAT5B CAND1 CAND1 PCNA PCNA NEDD8 NEDD8 CUL1 CUL1 DDB2 DDB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB1Damage specific DNA binding protein 1. (1140 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
UBE2FUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
STAT4Signal transducer and activator of transcription. (752 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
LOC100339305Uncharacterized protein. (506 aa)
VHLUncharacterized protein. (191 aa)
EME1Essential meiotic structure-specific endonuclease 1. (574 aa)
SAE1SUMO1 activating enzyme subunit 1. (326 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (277 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (227 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
CRLS1Cardiolipin synthase 1. (213 aa)
RAD50Zinc-hook domain-containing protein. (1269 aa)
CDT1Chromatin licensing and DNA replication factor 1. (365 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (680 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
FBXO3F-box domain-containing protein. (255 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1546 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
ELOBElongin B. (118 aa)
STAG2Stromal antigen 2 isoform a (Predicted). (1268 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
ATRXATRX chromatin remodeler. (2472 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1743 aa)
IRS1Insulin receptor substrate 1. (1220 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
CAND1Cullin associated and neddylation dissociated 1. (1207 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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