(9 nodes) (2015) Down-Regulation of Renal Gluconeogenesis in Type II Diabetic Rats Following Roux-en-Y Gastric Bypass Surgery: A Potential Mechanism in Hypoglycemic Effect. network (Oryctolagus cuniculus)

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Your Input:
	G6PC3	Glucose-6-phosphatase catalytic subunit 3. (562 aa)
	PXDN	Peroxidasin. (1411 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
	G6PC	Glucose-6-phosphatase catalytic subunit. (359 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	INSR	Tyrosine-protein kinase receptor. (1377 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	G6PC	ENSOCUP00000020897	ENSOCUP00000013761	C1q domain-containing protein.	Glucose-6-phosphatase catalytic subunit.	0.572
ADIPOQ	G6PC2	ENSOCUP00000020897	ENSOCUP00000001179	C1q domain-containing protein.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.543
ADIPOQ	G6PC3	ENSOCUP00000020897	ENSOCUP00000033043	C1q domain-containing protein.	Glucose-6-phosphatase catalytic subunit 3.	0.535
ADIPOQ	INS	ENSOCUP00000020897	ENSOCUP00000020463	C1q domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.939
ADIPOQ	INSR	ENSOCUP00000020897	ENSOCUP00000042281	C1q domain-containing protein.	Tyrosine-protein kinase receptor.	0.546
ADIPOQ	LEP	ENSOCUP00000020897	ENSOCUP00000008782	C1q domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.988
ADIPOQ	PXDN	ENSOCUP00000020897	ENSOCUP00000022906	C1q domain-containing protein.	Peroxidasin.	0.697
ADIPOQ	PXDNL	ENSOCUP00000020897	ENSOCUP00000004823	C1q domain-containing protein.	Peroxidasin like.	0.697
G6PC	ADIPOQ	ENSOCUP00000013761	ENSOCUP00000020897	Glucose-6-phosphatase catalytic subunit.	C1q domain-containing protein.	0.572
G6PC	G6PC2	ENSOCUP00000013761	ENSOCUP00000001179	Glucose-6-phosphatase catalytic subunit.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.939
G6PC	G6PC3	ENSOCUP00000013761	ENSOCUP00000033043	Glucose-6-phosphatase catalytic subunit.	Glucose-6-phosphatase catalytic subunit 3.	0.910
G6PC	INS	ENSOCUP00000013761	ENSOCUP00000020463	Glucose-6-phosphatase catalytic subunit.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.817
G6PC	INSR	ENSOCUP00000013761	ENSOCUP00000042281	Glucose-6-phosphatase catalytic subunit.	Tyrosine-protein kinase receptor.	0.533
G6PC	LEP	ENSOCUP00000013761	ENSOCUP00000008782	Glucose-6-phosphatase catalytic subunit.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.583
G6PC2	ADIPOQ	ENSOCUP00000001179	ENSOCUP00000020897	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	C1q domain-containing protein.	0.543
G6PC2	G6PC	ENSOCUP00000001179	ENSOCUP00000013761	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase catalytic subunit.	0.939
G6PC2	G6PC3	ENSOCUP00000001179	ENSOCUP00000033043	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Glucose-6-phosphatase catalytic subunit 3.	0.908
G6PC2	INS	ENSOCUP00000001179	ENSOCUP00000020463	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.782
G6PC2	INSR	ENSOCUP00000001179	ENSOCUP00000042281	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Tyrosine-protein kinase receptor.	0.449
G6PC2	LEP	ENSOCUP00000001179	ENSOCUP00000008782	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.566