15 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FST	Follistatin. (310 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	JUN	BZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	G1TYG1_RABIT	Glyceraldehyde-3-phosphate dehydrogenase. (369 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	G1TJG6_RABIT	Glyceraldehyde-3-phosphate dehydrogenase. (305 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
	DIP2A	Disco interacting protein 2 homolog A. (1432 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIP2A	FST	ENSOCUP00000004182	ENSOCUP00000004047	Disco interacting protein 2 homolog A.	Follistatin.	0.554
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	FST	ENSOCUP00000037329	ENSOCUP00000004047	TGFb_propeptide domain-containing protein.	Follistatin.	0.426
ENSOCUP00000037329	G1TC56_RABIT	ENSOCUP00000037329	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.429
ENSOCUP00000037329	G1TJG6_RABIT	ENSOCUP00000037329	ENSOCUP00000017094	TGFb_propeptide domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.670
ENSOCUP00000037329	G1TYG1_RABIT	ENSOCUP00000037329	ENSOCUP00000022125	TGFb_propeptide domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.661
ENSOCUP00000037329	GAPDH	ENSOCUP00000037329	ENSOCUP00000044112	TGFb_propeptide domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.746
ENSOCUP00000037329	IFNG	ENSOCUP00000037329	ENSOCUP00000039594	TGFb_propeptide domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.750
ENSOCUP00000037329	IL1B	ENSOCUP00000037329	ENSOCUP00000021869	TGFb_propeptide domain-containing protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.814
ENSOCUP00000037329	IL21	ENSOCUP00000037329	ENSOCUP00000013142	TGFb_propeptide domain-containing protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.700
ENSOCUP00000037329	IL6	ENSOCUP00000037329	ENSOCUP00000017266	TGFb_propeptide domain-containing protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.818
ENSOCUP00000037329	JUN	ENSOCUP00000037329	ENSOCUP00000040325	TGFb_propeptide domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.606
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000037329	TLR4	ENSOCUP00000037329	ENSOCUP00000001909	TGFb_propeptide domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.587
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	FST	ENSOCUP00000044284	ENSOCUP00000004047	TGFb_propeptide domain-containing protein.	Follistatin.	0.426
ENSOCUP00000044284	G1TC56_RABIT	ENSOCUP00000044284	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.543
ENSOCUP00000044284	G1TJG6_RABIT	ENSOCUP00000044284	ENSOCUP00000017094	TGFb_propeptide domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.670
ENSOCUP00000044284	G1TYG1_RABIT	ENSOCUP00000044284	ENSOCUP00000022125	TGFb_propeptide domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.661
ENSOCUP00000044284	GAPDH	ENSOCUP00000044284	ENSOCUP00000044112	TGFb_propeptide domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.746