36 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	IGHM-3	Ig-like domain-containing protein. (167 aa)
	IRF8	Interferon regulatory factor 8. (455 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
	BRWD3	Bromodomain and WD repeat domain containing 3. (1527 aa)
	BRWD1	Bromodomain and WD repeat domain containing 1. (2220 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	IL7R	Interleukin 7 receptor. (458 aa)
	PAX5	Paired box 5. (371 aa)
	LOC100357927	Histone domain-containing protein. (136 aa)
	IKZF1	IKAROS family zinc finger 1. (515 aa)
	H3F3B	Histone H3; Belongs to the histone H3 family. (136 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
	IGLL1	Lambda5. (208 aa)
	H3C13	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100345683	Histone H3; Belongs to the histone H3 family. (136 aa)
	IGHM-2	Ig-like domain-containing protein. (167 aa)
	H3-3A	Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
	LOC100344410	Histone domain-containing protein. (136 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
	RAG2	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
	G1TX56_RABIT	Histone H3; Belongs to the histone H3 family. (136 aa)
	G1TJR7_RABIT	Histone H3; Belongs to the histone H3 family. (136 aa)
	CD4	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1653 aa)
	CD34	CD34 molecule. (415 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
	CD19	CD19 molecule. (573 aa)
	PLEK	Pleckstrin. (350 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (287 aa)
	ENSOCUP00000042583	Histone H3; Belongs to the histone H3 family. (115 aa)
	PLEK2	Pleckstrin 2. (354 aa)
	ACTG1	Actin gamma 1; Belongs to the actin family. (323 aa)
	CD44	CD44 molecule (Indian blood group). (761 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG1	SMARCA4	ENSOCUP00000044872	ENSOCUP00000032053	Actin gamma 1; Belongs to the actin family.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4.	0.531
B2M	CCND2	ENSOCUP00000014707	ENSOCUP00000013388	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.451
B2M	CD19	ENSOCUP00000014707	ENSOCUP00000036537	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD19 molecule.	0.540
B2M	CD34	ENSOCUP00000014707	ENSOCUP00000032705	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD34 molecule.	0.569
B2M	CD4	ENSOCUP00000014707	ENSOCUP00000030708	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.738
B2M	CD44	ENSOCUP00000014707	ENSOCUP00000048202	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD44 molecule (Indian blood group).	0.544
B2M	ENSOCUP00000042583	ENSOCUP00000014707	ENSOCUP00000042583	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3; Belongs to the histone H3 family.	0.558
B2M	ESR1	ENSOCUP00000014707	ENSOCUP00000004174	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.416
B2M	G1TJR7_RABIT	ENSOCUP00000014707	ENSOCUP00000025681	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3; Belongs to the histone H3 family.	0.558
B2M	G1TX56_RABIT	ENSOCUP00000014707	ENSOCUP00000021656	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3; Belongs to the histone H3 family.	0.558
B2M	H3-3A	ENSOCUP00000014707	ENSOCUP00000018693	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...]	0.560
B2M	H3C13	ENSOCUP00000014707	ENSOCUP00000016501	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3; Belongs to the histone H3 family.	0.558
B2M	H3F3B	ENSOCUP00000014707	ENSOCUP00000012877	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3; Belongs to the histone H3 family.	0.557
B2M	IGHM-2	ENSOCUP00000014707	ENSOCUP00000018495	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.444
B2M	IGHM-3	ENSOCUP00000014707	ENSOCUP00000025645	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.445
B2M	KIT	ENSOCUP00000014707	ENSOCUP00000034895	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.419
B2M	LOC100344410	ENSOCUP00000014707	ENSOCUP00000019185	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone domain-containing protein.	0.558
B2M	LOC100345683	ENSOCUP00000014707	ENSOCUP00000017475	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone H3; Belongs to the histone H3 family.	0.559
B2M	LOC100357927	ENSOCUP00000014707	ENSOCUP00000012002	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Histone domain-containing protein.	0.558
BRWD1	SMARCA4	ENSOCUP00000007670	ENSOCUP00000032053	Bromodomain and WD repeat domain containing 1.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4.	0.637