STRINGSTRING
CUL3 CUL3 PXDN PXDN SKP1 SKP1 CDC34 CDC34 CUL2 CUL2 FBXL3 FBXL3 CUL5 CUL5 CUL4A CUL4A UBA1 UBA1 UBA3 UBA3 PXDNL PXDNL CUL9 CUL9 NEDD8 NEDD8 CUL1 CUL1 UBL3 UBL3 CUL7 CUL7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
PXDNPeroxidasin. (1411 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (227 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (463 aa)
PXDNLPeroxidasin like. (1467 aa)
CUL9Cullin 9; Belongs to the cullin family. (2580 aa)
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
UBL3Ubiquitin-like protein. (117 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.