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HNRNPU HNRNPU SPEN SPEN GAPDH GAPDH EZH2 EZH2 PCDHB5 PCDHB5 CKB CKB ACTB ACTB CKMT1A CKMT1A HOXD10 HOXD10 HSF5 HSF5 JARID2 JARID2 HNRNPK HNRNPK CKMT2 CKMT2 HNRNPA1 HNRNPA1 FUS FUS HNRNPL HNRNPL SDHA SDHA JAM2 JAM2 PCDH10 PCDH10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (844 aa)
SPENSpen family transcriptional repressor. (3600 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
PCDHB5Protocadherin beta 5. (919 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (425 aa)
ACTBUncharacterized protein. (357 aa)
CKMT1ACreatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
HOXD10Homeobox domain-containing protein. (410 aa)
HSF5Heat shock transcription factor 5. (604 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1242 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)
CKMT2Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (419 aa)
HNRNPA1Uncharacterized protein. (371 aa)
FUSFUS RNA binding protein. (517 aa)
HNRNPLHeterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (686 aa)
JAM2Junctional adhesion molecule 2. (297 aa)
PCDH10Protocadherin 10. (1055 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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