STRINGSTRING
LOC100357927 LOC100357927 CD48 CD48 PAX5 PAX5 GLB1L3 GLB1L3 EBF1 EBF1 EGR1 EGR1 CCR9 CCR9 LMNB1 LMNB1 GLB1 GLB1 FLT3 FLT3 ID2 ID2 G1TX56_RABIT G1TX56_RABIT GFI1 GFI1 G1TJR7_RABIT G1TJR7_RABIT IL7 IL7 CD4 CD4 KIT KIT CD19 CD19 GAPDH GAPDH RAG1 RAG1 LOC100344410 LOC100344410 H3-3A H3-3A ENSOCUP00000042583 ENSOCUP00000042583 LOC100345683 LOC100345683 H3C13 H3C13 H3F3B H3F3B CD93 CD93 FOXO1 FOXO1 GLB1L2 GLB1L2 CD44 CD44 LOC103345097 LOC103345097 DNTT DNTT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100357927Histone domain-containing protein. (136 aa)
CD48Ig-like domain-containing protein. (291 aa)
PAX5Paired box 5. (371 aa)
GLB1L3Beta-galactosidase. (654 aa)
EBF1EBF transcription factor 1. (591 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (609 aa)
GLB1Beta-galactosidase. (843 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
ID2Inhibitor of DNA binding 2. (109 aa)
G1TX56_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
GFI1Growth factor independent 1 transcriptional repressor. (423 aa)
G1TJR7_RABITHistone H3; Belongs to the histone H3 family. (136 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CD19CD19 molecule. (573 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
LOC100344410Histone domain-containing protein. (136 aa)
H3-3AHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
ENSOCUP00000042583Histone H3; Belongs to the histone H3 family. (115 aa)
LOC100345683Histone H3; Belongs to the histone H3 family. (136 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
CD93CD93 molecule. (653 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
GLB1L2Beta-galactosidase. (699 aa)
CD44CD44 molecule (Indian blood group). (761 aa)
LOC103345097Beta-galactosidase. (683 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (569 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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