21 items (Oryctolagus cuniculus) - STRING interaction network

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	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	MMP13	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
	FST	Follistatin. (310 aa)
	PXDNL	Peroxidasin like. (1467 aa)
	GLB1	Beta-galactosidase. (843 aa)
	GLB1L3	Beta-galactosidase. (654 aa)
	RHOA	Ras homolog family member A. (193 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
	PXDN	Peroxidasin. (1411 aa)
	MMP9	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
	CDC42-2	Uncharacterized protein. (222 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	MMP2	72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (710 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	CDC42	Uncharacterized protein. (191 aa)
	GLB1L2	Beta-galactosidase. (699 aa)
	LOC103345097	Beta-galactosidase. (683 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	IL1B	ENSOCUP00000047724	ENSOCUP00000021869	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.461
CDC42	IL6	ENSOCUP00000047724	ENSOCUP00000017266	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.466
CDC42	MMP2	ENSOCUP00000047724	ENSOCUP00000034116	Uncharacterized protein.	72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...]	0.434
CDC42	MMP9	ENSOCUP00000047724	ENSOCUP00000025066	Uncharacterized protein.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.614
CDC42	PXDN	ENSOCUP00000047724	ENSOCUP00000022906	Uncharacterized protein.	Peroxidasin.	0.700
CDC42	PXDNL	ENSOCUP00000047724	ENSOCUP00000004823	Uncharacterized protein.	Peroxidasin like.	0.700
CDC42	RHOA	ENSOCUP00000047724	ENSOCUP00000011466	Uncharacterized protein.	Ras homolog family member A.	0.615
CDC42	TLR4	ENSOCUP00000047724	ENSOCUP00000001909	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.448
CDC42-2	IL1B	ENSOCUP00000025997	ENSOCUP00000021869	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.467
CDC42-2	IL6	ENSOCUP00000025997	ENSOCUP00000017266	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.471
CDC42-2	MMP2	ENSOCUP00000025997	ENSOCUP00000034116	Uncharacterized protein.	72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...]	0.451
CDC42-2	MMP9	ENSOCUP00000025997	ENSOCUP00000025066	Uncharacterized protein.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.618
CDC42-2	PXDN	ENSOCUP00000025997	ENSOCUP00000022906	Uncharacterized protein.	Peroxidasin.	0.700
CDC42-2	PXDNL	ENSOCUP00000025997	ENSOCUP00000004823	Uncharacterized protein.	Peroxidasin like.	0.700
CDC42-2	RHOA	ENSOCUP00000025997	ENSOCUP00000011466	Uncharacterized protein.	Ras homolog family member A.	0.506
CDC42-2	TLR4	ENSOCUP00000025997	ENSOCUP00000001909	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.458
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	FST	ENSOCUP00000037329	ENSOCUP00000004047	TGFb_propeptide domain-containing protein.	Follistatin.	0.426
ENSOCUP00000037329	G1TC56_RABIT	ENSOCUP00000037329	ENSOCUP00000014344	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.429
ENSOCUP00000037329	IFNG	ENSOCUP00000037329	ENSOCUP00000039594	TGFb_propeptide domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.750