node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHR | ESR1 | ENSOCUP00000042767 | ENSOCUP00000004174 | Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.650 |
AHR | LOC100358544 | ENSOCUP00000042767 | ENSOCUP00000022150 | Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] | Uncharacterized protein. | 0.905 |
CCND2 | ESR1 | ENSOCUP00000013388 | ENSOCUP00000004174 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.751 |
CCND2 | PPARG | ENSOCUP00000013388 | ENSOCUP00000043929 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.439 |
CLCA2 | CLCN6 | ENSOCUP00000004086 | ENSOCUP00000006313 | Chloride channel accessory 2. | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 6/CLCN6 subfamily. | 0.584 |
CLCA2 | NCKAP5L | ENSOCUP00000004086 | ENSOCUP00000001592 | Chloride channel accessory 2. | NCK associated protein 5 like. | 0.723 |
CLCA2 | TEX2 | ENSOCUP00000004086 | ENSOCUP00000036784 | Chloride channel accessory 2. | Testis expressed 2. | 0.558 |
CLCN6 | CLCA2 | ENSOCUP00000006313 | ENSOCUP00000004086 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 6/CLCN6 subfamily. | Chloride channel accessory 2. | 0.584 |
CLCN6 | NCKAP5L | ENSOCUP00000006313 | ENSOCUP00000001592 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 6/CLCN6 subfamily. | NCK associated protein 5 like. | 0.437 |
CLCN6 | TEX2 | ENSOCUP00000006313 | ENSOCUP00000036784 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 6/CLCN6 subfamily. | Testis expressed 2. | 0.566 |
DNAJC14 | NCKAP5L | ENSOCUP00000019968 | ENSOCUP00000001592 | J domain-containing protein. | NCK associated protein 5 like. | 0.697 |
DNAJC14 | TEX2 | ENSOCUP00000019968 | ENSOCUP00000036784 | J domain-containing protein. | Testis expressed 2. | 0.567 |
ESR1 | AHR | ENSOCUP00000004174 | ENSOCUP00000042767 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] | 0.650 |
ESR1 | CCND2 | ENSOCUP00000004174 | ENSOCUP00000013388 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.751 |
ESR1 | ETS2 | ENSOCUP00000004174 | ENSOCUP00000020018 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | ETS proto-oncogene 2, transcription factor; Transcription factor; Belongs to the ETS family. | 0.582 |
ESR1 | LOC100358544 | ENSOCUP00000004174 | ENSOCUP00000022150 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Uncharacterized protein. | 0.469 |
ESR1 | PPARG | ENSOCUP00000004174 | ENSOCUP00000043929 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.668 |
ETS2 | ESR1 | ENSOCUP00000020018 | ENSOCUP00000004174 | ETS proto-oncogene 2, transcription factor; Transcription factor; Belongs to the ETS family. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.582 |
LOC100358544 | AHR | ENSOCUP00000022150 | ENSOCUP00000042767 | Uncharacterized protein. | Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] | 0.905 |
LOC100358544 | ESR1 | ENSOCUP00000022150 | ENSOCUP00000004174 | Uncharacterized protein. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.469 |