STRINGSTRING
SMAD4 SMAD4 CCN2 CCN2 GAPDH GAPDH ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000037329 ENSOCUP00000037329 TGFBR1 TGFBR1 LOC103345451 LOC103345451 TGFBR2 TGFBR2 VWF VWF PXDN PXDN SNAI1 SNAI1 G1TC56_RABIT G1TC56_RABIT TGFBR3 TGFBR3 COL3A1 COL3A1 EDN1 EDN1 COL1A1 COL1A1 SNAI2 SNAI2 TGFB3 TGFB3 SMAD2 SMAD2 PXDNL PXDNL TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CCN2Cellular communication network factor 2. (437 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
VWFVon Willebrand factor. (2788 aa)
PXDNPeroxidasin. (1411 aa)
SNAI1Snail family transcriptional repressor 1. (238 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
SNAI2Uncharacterized protein. (268 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PXDNLPeroxidasin like. (1467 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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