STRINGSTRING
PDCD4 PDCD4 DROSHA DROSHA HNRNPD HNRNPD CUL7 CUL7 CUL1 CUL1 CUL9 CUL9 KLHL12 KLHL12 CUL4A CUL4A EIF4A1 EIF4A1 CUL5 CUL5 HNRNPA1 HNRNPA1 CUL2 CUL2 NCL NCL PCBP2 PCBP2 FUBP1 FUBP1 LOC100353293 LOC100353293 EIF4G1 EIF4G1 CUL3 CUL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDCD4Programmed cell death 4. (491 aa)
DROSHADrosha ribonuclease III. (1365 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (286 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
CUL9Cullin 9; Belongs to the cullin family. (2580 aa)
KLHL12Kelch like family member 12. (851 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
EIF4A1Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. (406 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
HNRNPA1Uncharacterized protein. (371 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
NCLNucleolin. (721 aa)
PCBP2Poly(rC) binding protein 2. (366 aa)
FUBP1Uncharacterized protein. (689 aa)
LOC100353293Uncharacterized protein. (321 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. (1608 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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