STRINGSTRING
TGFBR2 TGFBR2 SMAD3 SMAD3 CDC42-2 CDC42-2 PXDN PXDN INS INS SNAI1 SNAI1 ZEB2 ZEB2 ACVR1B ACVR1B ACVR2A ACVR2A EGF EGF RHOA RHOA SNAI2 SNAI2 TGFB3 TGFB3 SMAD2 SMAD2 ACVR1C ACVR1C NODAL NODAL ZEB1 ZEB1 PXDNL PXDNL TGFB2 TGFB2 INHBB INHBB FST FST ACVR1 ACVR1 INHBA INHBA CDC42 CDC42 GRB2 GRB2 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SMAD3SMAD family member 3. (230 aa)
CDC42-2Uncharacterized protein. (222 aa)
PXDNPeroxidasin. (1411 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
SNAI1Snail family transcriptional repressor 1. (238 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1188 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
RHOARas homolog family member A. (193 aa)
SNAI2Uncharacterized protein. (268 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
NODALNodal growth differentiation factor. (348 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
PXDNLPeroxidasin like. (1467 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
INHBBInhibin subunit beta B. (302 aa)
FSTFollistatin. (310 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
INHBAInhibin subunit beta A. (424 aa)
CDC42Uncharacterized protein. (191 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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