STRINGSTRING
GAPDH GAPDH PNN PNN CUL1 CUL1 CUL4A CUL4A CUL5 CUL5 CUL7 CUL7 KRAS KRAS CUL2 CUL2 G1TJG6_RABIT G1TJG6_RABIT G1TYG1_RABIT G1TYG1_RABIT CUL3 CUL3 BRAF BRAF CUL4B CUL4B DDB2 DDB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
PNNPinin, desmosome associated protein. (735 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
CUL7Cullin 7; Belongs to the cullin family. (1728 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
G1TJG6_RABITGlyceraldehyde-3-phosphate dehydrogenase. (305 aa)
G1TYG1_RABITGlyceraldehyde-3-phosphate dehydrogenase. (369 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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