STRINGSTRING
KLHL15 KLHL15 MYF5 MYF5 TNNT3 TNNT3 RPS20 RPS20 PCNA PCNA ACTA1 ACTA1 CHD1 CHD1 PXDNL PXDNL PAX7 PAX7 PSMC1 PSMC1 RPS3A RPS3A MARCKS MARCKS ACTC1 ACTC1 RPS3A-2 RPS3A-2 TNNC1 TNNC1 TNNI1 TNNI1 MYOG MYOG MSTN MSTN RPLP1 RPLP1 DMD DMD SMYD1 SMYD1 RPS25 RPS25 PAX3 PAX3 G1TGN8_RABIT G1TGN8_RABIT RPS3A-3 RPS3A-3 RPS3A-4 RPS3A-4 NDUFB9 NDUFB9 CYCS CYCS ADSS2 ADSS2 ENSOCUP00000022874 ENSOCUP00000022874 PXDN PXDN ENSOCUP00000024017 ENSOCUP00000024017 RPS3A-5 RPS3A-5 RPS3A-6 RPS3A-6 RPS3A-7 RPS3A-7 PRDX3 PRDX3 RPL4 RPL4 MYL2 MYL2 MYL3 MYL3 NDUFA5 NDUFA5 ARF4 ARF4 PDHA1 PDHA1 PDK3 PDK3 STMN1 STMN1 ARF4-2 ARF4-2 TPM2 TPM2 NDUFS6 NDUFS6 ATP2A2 ATP2A2 NDUFA12 NDUFA12 MYL1 MYL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLHL15Kelch like family member 15. (604 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
TNNT3Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (202 aa)
RPS20Ribosomal_S10 domain-containing protein. (119 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ACTA1Actin, alpha skeletal muscle. (369 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1537 aa)
PXDNLPeroxidasin like. (1467 aa)
PAX7Paired box 7. (476 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
RPS3A40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (333 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
RPS3A-240S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (239 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa)
TNNI1Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (187 aa)
MYOGMyogenin. (225 aa)
MSTNMyostatin. (375 aa)
RPLP1Ribosomal protein lateral stalk subunit P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
DMDUncharacterized protein. (956 aa)
SMYD1SET and MYND domain containing 1. (490 aa)
RPS2540S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (124 aa)
PAX3Paired box 3. (484 aa)
G1TGN8_RABITAdenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (333 aa)
RPS3A-340S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (422 aa)
RPS3A-440S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
NDUFB9NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (209 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ADSS2Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (421 aa)
ENSOCUP00000022874annotation not available (264 aa)
PXDNPeroxidasin. (1411 aa)
ENSOCUP00000024017annotation not available (264 aa)
RPS3A-540S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (244 aa)
RPS3A-640S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
RPS3A-740S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
PRDX3Thioredoxin domain-containing protein. (307 aa)
RPL4Ribos_L4_asso_C domain-containing protein. (439 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (232 aa)
MYL3Myosin light chain 3. (327 aa)
NDUFA5Uncharacterized protein. (142 aa)
ARF4Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (186 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (399 aa)
PDK3Protein-serine/threonine kinase. (439 aa)
STMN1Stathmin; Belongs to the stathmin family. (164 aa)
ARF4-2Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (163 aa)
TPM2Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. (352 aa)
NDUFS6zf-CHCC domain-containing protein. (225 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1017 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (145 aa)
MYL1Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (193 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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