20 items (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
	PDK3	Protein-serine/threonine kinase. (439 aa)
	CD19	CD19 molecule. (573 aa)
	IRF8	Interferon regulatory factor 8. (455 aa)
	GFRA2	GDNF family receptor alpha 2. (345 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	EBF1	EBF transcription factor 1. (591 aa)
	IRF4	Interferon regulatory factor 4. (451 aa)
	VCAM1	Uncharacterized protein. (828 aa)
	PAX5	Paired box 5. (371 aa)
	FOXO1	Fork-head domain-containing protein. (613 aa)
	SPIB	ETS domain-containing protein. (158 aa)
	IGHM-2	Ig-like domain-containing protein. (167 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
	RAG2	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
	IGHM-3	Ig-like domain-containing protein. (167 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1192 aa)
	CD40	Uncharacterized protein. (494 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD19	CD40	ENSOCUP00000036537	ENSOCUP00000034264	CD19 molecule.	Uncharacterized protein.	0.872
CD19	CD40LG	ENSOCUP00000036537	ENSOCUP00000003395	CD19 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.830
CD19	EBF1	ENSOCUP00000036537	ENSOCUP00000007763	CD19 molecule.	EBF transcription factor 1.	0.597
CD19	FOXO1	ENSOCUP00000036537	ENSOCUP00000012389	CD19 molecule.	Fork-head domain-containing protein.	0.424
CD19	IGHM-2	ENSOCUP00000036537	ENSOCUP00000018495	CD19 molecule.	Ig-like domain-containing protein.	0.775
CD19	IGHM-3	ENSOCUP00000036537	ENSOCUP00000025645	CD19 molecule.	Ig-like domain-containing protein.	0.775
CD19	IL4	ENSOCUP00000036537	ENSOCUP00000025135	CD19 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.885
CD19	IL7	ENSOCUP00000036537	ENSOCUP00000038193	CD19 molecule.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.789
CD19	IRF4	ENSOCUP00000036537	ENSOCUP00000008085	CD19 molecule.	Interferon regulatory factor 4.	0.722
CD19	IRF8	ENSOCUP00000036537	ENSOCUP00000000464	CD19 molecule.	Interferon regulatory factor 8.	0.584
CD19	PAX5	ENSOCUP00000036537	ENSOCUP00000010574	CD19 molecule.	Paired box 5.	0.833
CD19	RAG1	ENSOCUP00000036537	ENSOCUP00000020586	CD19 molecule.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.749
CD19	RAG2	ENSOCUP00000036537	ENSOCUP00000020912	CD19 molecule.	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...]	0.734
CD19	SPIB	ENSOCUP00000036537	ENSOCUP00000017492	CD19 molecule.	ETS domain-containing protein.	0.535
CD19	VCAM1	ENSOCUP00000036537	ENSOCUP00000010056	CD19 molecule.	Uncharacterized protein.	0.538
CD40	CD19	ENSOCUP00000034264	ENSOCUP00000036537	Uncharacterized protein.	CD19 molecule.	0.872
CD40	CD40LG	ENSOCUP00000034264	ENSOCUP00000003395	Uncharacterized protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.999
CD40	IGHM-2	ENSOCUP00000034264	ENSOCUP00000018495	Uncharacterized protein.	Ig-like domain-containing protein.	0.672
CD40	IGHM-3	ENSOCUP00000034264	ENSOCUP00000025645	Uncharacterized protein.	Ig-like domain-containing protein.	0.675
CD40	IL4	ENSOCUP00000034264	ENSOCUP00000025135	Uncharacterized protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.879