19 items (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	HYAL3	Hyaluronidase. (492 aa)
	LOX	Lysyl oxidase. (419 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	CD44	CD44 molecule (Indian blood group). (761 aa)
	HYAL2	Hyaluronidase. (475 aa)
	HYAL1	Hyaluronidase. (497 aa)
	TYR	Uncharacterized protein. (530 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	BMP2	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
	SPARC	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (315 aa)
	HYAL4	Hyaluronidase. (484 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	BGLAP	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
	SPP1	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (311 aa)
	LOC100337977	Hyaluronidase. (480 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	ENSOCUP00000040886	Uncharacterized protein. (420 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BGLAP	BMP2	ENSOCUP00000020318	ENSOCUP00000010036	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	0.877
BGLAP	CD44	ENSOCUP00000020318	ENSOCUP00000048202	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	CD44 molecule (Indian blood group).	0.604
BGLAP	ENSOCUP00000037329	ENSOCUP00000020318	ENSOCUP00000037329	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	TGFb_propeptide domain-containing protein.	0.569
BGLAP	ENSOCUP00000044284	ENSOCUP00000020318	ENSOCUP00000044284	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	TGFb_propeptide domain-containing protein.	0.569
BGLAP	G1TC56_RABIT	ENSOCUP00000020318	ENSOCUP00000014344	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	TGFb_propeptide domain-containing protein.	0.524
BGLAP	LOC103345451	ENSOCUP00000020318	ENSOCUP00000031740	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	TGFb_propeptide domain-containing protein.	0.569
BGLAP	SPARC	ENSOCUP00000020318	ENSOCUP00000010426	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family.	0.959
BGLAP	SPP1	ENSOCUP00000020318	ENSOCUP00000021885	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family.	0.974
BMP2	BGLAP	ENSOCUP00000010036	ENSOCUP00000020318	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	0.877
BMP2	CD44	ENSOCUP00000010036	ENSOCUP00000048202	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	CD44 molecule (Indian blood group).	0.555
BMP2	ENSOCUP00000037329	ENSOCUP00000010036	ENSOCUP00000037329	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.730
BMP2	ENSOCUP00000044284	ENSOCUP00000010036	ENSOCUP00000044284	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.730
BMP2	G1TC56_RABIT	ENSOCUP00000010036	ENSOCUP00000014344	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.726
BMP2	LOC103345451	ENSOCUP00000010036	ENSOCUP00000031740	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	TGFb_propeptide domain-containing protein.	0.730
BMP2	SMO	ENSOCUP00000010036	ENSOCUP00000027051	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.442
BMP2	SPARC	ENSOCUP00000010036	ENSOCUP00000010426	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family.	0.753
BMP2	SPP1	ENSOCUP00000010036	ENSOCUP00000021885	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family.	0.906
CD44	BGLAP	ENSOCUP00000048202	ENSOCUP00000020318	CD44 molecule (Indian blood group).	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.	0.604
CD44	BMP2	ENSOCUP00000048202	ENSOCUP00000010036	CD44 molecule (Indian blood group).	Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.	0.555
CD44	ENSOCUP00000037329	ENSOCUP00000048202	ENSOCUP00000037329	CD44 molecule (Indian blood group).	TGFb_propeptide domain-containing protein.	0.617